Human vault RNA

Details Human vault RNA Human vault RNA

1999-03-26

2000-08-29

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 911, 4352523, 4353201, 536 231, 536 2351, 536 243, 536 2431, 536 2433, C07H 2102, C07H 2104, C12N 1563, C12N 1585, C12Q 168

Patent

active

061107409

ABSTRACT:
A polynucleotide encoding a human vault-associated vRNA or its complementary strand. A purified and isolated polynucleotide molecule consisting essentially of a human vault RNA, or its complementary strands, or a combination of a nucleotide sequence consisting essentially of a human vault RNA and its complementary strands. A method of diagnosing a patient with a multidrug-resistant cancer. A method of treating a patient with multidrug-resistant cancer. A composition for treating multidrug-resistant cancer comprising a polynucleotide which hybridizes with a human vault-associated vRNA. A method of screening for compositions for treating a patient with multidrug-resistant cancer.

REFERENCES:
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George, David G. et al. Current Methods in Sequence Comparison and Analysis. Macromolecular Sequencing and Synthesis Selected Methods and Applications, 1988, pp. 127-149, Alan R. Liss, Inc., New York.
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Kickhoefer, V.A. et al., "Vaults are the answer, what is the question?," Trends in Cell Biology, 6(5):174-178 1996.

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