Human vanilloid receptor VR3 protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C514S002600, C536S023500, C435S069100

Reexamination Certificate

active

10985156

ABSTRACT:
DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

REFERENCES:
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 6335180 (2002-01-01), Julius et al.
patent: 6455278 (2002-09-01), Dubin et al.
patent: 1160254 (2001-12-01), None
patent: WO 99/37765 (1999-07-01), None
patent: WO 9937765 (1999-07-01), None
patent: WO 0032766 (2000-06-01), None
patent: WO 0134805 (2001-05-01), None
Skolnick et al. (2000). From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech. 18(1):34-39.
Bork, A. (2000). Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res. 10:398-400.
Doerks et al. (1998). Protein annotation: detective work for function prediction. Trends in Genetics. 14(6):248-250.
Smith et al. (1997). The challenges of genome sequence annotation or The devil is in the details. Nature Biotech. 15:1222-1223.
Brenner, S.E. (1999). Errors in genome function. Trends in Genetics. 15(4):132-133.
Bork et al. (1996) Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10):425-427.
Caterina et al. (1999). A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 398:436-441.
Bevan et al., “Capsazepine: A Competitive Antagonist of the Sensory Neurone Excitant Capsaicin”,Br. J. Pharmacol., (1992) 107:544-552.
S. Bevan and J. Szolcsanyi, “Sensory Neuron-Specific Actions of Capsaicin: Mechanisms and Applications”,TiPS(Aug. 1990) vol. 11.
Caterina et al., “A Capsaicin-Receptor Homologue with a High Threshold for Noxious Heat”,Letters to Nature, (1999) 398.
P. D. Gubpta and K. Pushkala, “Importance of the Role of Calcium in Programmed Cell Death: A Review”,Cytobios(1999) 99:83-95.
Leeman et al., “Substance P and Related Peptides: Cellular and Molecular Physiology”,Ann. N.Y. Academy of Sciences, (1991) 632.
B. Minke and Z. Selinger, “The Roles of TRP and Calcium in Regulating Photoreceptor Function in Drosophila”,Neurobiology, (1996) 6:459-466.
Oh et al., “Capsaicin Activates a Nonselective Cation Channel in Cultured Neonatal Rat Dorsal Root Ganglion Neurons”,J. Neurosciences, (1996) 16(5):1659-1667.
M. D. Szallasi, “ARPAD: Autoradiographic Visualization and Pharmacological Characterization of Vanilloid (Capsaicin) Receptors in Several Species Including Man”,ACTA Physiologica Scandinavica(1995) Supplement. 629, Stockholm, Sweden.
J. Szolcsanyi, “Capsaicin-Sensitive Sensory Nerve Terminals with Local and Systemic Efferent Functions: Facts and Scopes of an Unorthodox Neuroregulatory Mechanism”,Progress in Brain Research, (1996) 113.
Tominaga et al., “The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli”,Neuron(1998) 21:531-543.
Wood et al., “Capsaicin-Induced Ion Fluxes in Dorsal Root Ganglion Cells in Culture”,J. Neuroscience(1988) 8(9): 3206:3220.
Barry, “JPCalc, A Software Package For Calculating Liquid Junction Potential Corrections In Patch-Clamp, Intracellular, Epithelial And Bilayer Measurements And For Correcting Junction Potential Measurements”,J. Neurosci. Methods, vol. 51, pp. 107-116 (1994).
Blackstone et al, “Protein Targeting And Calcium Signaling Microdomains In Neuronal Cells”,Call Calcium, vol. 26(5), pp. 181-192 (1999).
Caterina et al., “The Capsaicin Receptor: A Heat-Activated Ion Channel In The Pain Pathway”,Nature, vol. 389, pp. 816-824 (1997).
Dubin et al., “Lysophosphatidic Acid Stimulates Neurotransmitter-Like Conductance Changes That Precede GABA And L-glutamate In Early, Presumptive Cortical Neuroblasts”,J. Neurosci., vol. 19(4), pp. 1371-1381 (1999).
Ecker et al., “Increasing Gene Expression In Yeast By Fusion To Ubiquitin”,J. Biol. Chem., vol. 264(13), pp. 7715-7719 (1989).
Horowitz et al., “Synthesis And Assembly Of Functional Mammalian Na,K-ATPase In Yeast”,J. Biol. Chem., vol. 265(8), pp. 4189-4192 (1990).
Jacobson et al., “Expression And Secretion Of Biologically Active Echistatin InSaccharomyces cerevisiae”,Gene, vol. 85, pp. 511-516 (1989).
Kaufman et al., “Amplification And Expression Of Sequences Cotransfected With A Modular Dihydrofolate Reductase Complementary DNA Gene”,J. Mol. Biol., vol. 159, pp. 601-621 (1892).
Kitts et al., “Linearization Of Baculovirus DNA Enhances The Recovery Of Recombinant Virus Expression Vectors”,Nucleic Acids Res., vol. 18(19), pp. 5667-5672 (1990).
Kohler et al., “Continuous Cultures Of Fused Cells Secreting Antibody Of Predefined Specificity”,Nature, vol. 256, pp. 495-497 (1975).
Lu et al., “A DNA Deletion Associated With Multiple Impaired Transcripts In The Visual Mutant TRP”,Invest. Ophthalmol. Visual Sci., vol. 28, pp. 2092-2095 (1987).
Luo et al., “Gene Expression Profiles Of Laser-Captured Adjacent Neuronal Subtypes”,Nat. Med., vol. 5(1), pp. 117-121 (1999).
McDonnell et al., “Reconstitution Of The Vitamin D-Responsive Osteocalcin Transcription Unit InSaccharomyces cerevisiae”,Mol. Cell. Biol., vol. 9(8), pp. 3517-3523 (1989).
Mikayama et al., “Molecular Cloning And Functional Expression Of A cDNA Encoding Clycosylation-Inhibiting Factor”,Proc. Natl. Acad. Sci. USA, vol. 90, pp. 10056-10060 (1993).
Minke et al., “The Roles Of trp And Calcium In Regulating Photoreceptor Function In Drosophila”,Curr. Opin. Neurobiol, vol. 6(4), pp. 459-466 (1996).
Riehl-Bellon et al., “Purification And Biochemical Characterization Of Recombinant Hirudin Produced BySaccharomyces cerevisiae”,Biochemistry, vol. 28, pp. 2941-2949 (1989).
Rinas et al., “Characterization of Recombinant Factor XIIIa Produced InSaccharomyces cerevisiae”,Biotechnology, vol. 8, pp. 543-545 (1990).
Sabin et al., “High-Level Expression An In Vivo Processing Of Chimeric Ubiquitin Fusion Proteins I nSaccharomyces cerivisiae”,Biotechnology, vol. 7, pp. 705-709 (1989).
Siekevitz et al., “Activation Of The HIV-1 LTR By T Cell Mitogens And The Trans-Activator Protein Of HTLV-I”,Science, vol. 238(4833), pp. 1575-1578 (1987).
Sleep et al., “The Secretion Of Human Serum Albumin From The YeastSaccharomyces cerevisiaeUsing Five Different Leader Sequences”,Biotechnology, vol. 8, pp. 42-46 (1990).
Suzuki et al., “Cloning Of A Stretch-Inhibitable Nonselective Cation Channel”,J. Biol. Chem., vol. 274(10), pp. 6330-6335 (1999).
Szolcsanyi, “Actions Of Capsaicin On Sensory Receptors”,Capsaicin In The Study Of Pain(Wood, ed.), Academic Press, London, UK, pp. 1-26 (1993).
Szolcsanyi, “Resiniferatoxin. An Ultrapotent Neurotoxin Of Capsaicin-Sensitive Primary Afferent Neurons”,Ann. N. Y. Acad. Sci., vol. 632, pp. 473-475 (1991).
Van Haasteren et al., “Calcium Signaling And Gene Expression”,J. Recept. Signal Transduction Res., vol. 19(1-4), pp. 481-492 (1999).
Voet et al.,Biochemistry, John Wiley & Sons, pp. 126-128 and 228-234 (1990).
Wigler et al., “Transfer Of Purified Herpes Virus Thymidine Kinase Gene To Cultured Mouse Cells”,Cell, vol. 11, pp. 223-232 (1977).
Yamamoto et al., “Important Role Of The Proline Residue In The Signal Sequence That Directs The Secretion Of Human Lysozyme InSaccharomyces cerevisiae”,Biochemistry, vol. 28, pp. 2728-2732 (1989).
Lietdtke et al., “Vanilloid Receptor-Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor,”Cell, vol. 103,

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