Human vanilloid receptor VR3 protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C435S069100

Reexamination Certificate

active

07094877

ABSTRACT:
DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

REFERENCES:
patent: 6455278 (2002-09-01), Dubin et al.
patent: 1160254 (2001-12-01), None
patent: WO 99/37765 (1999-07-01), None
patent: WO 9937765 (1999-07-01), None
patent: WO 0032766 (2000-06-01), None
patent: WO 01/34805 (2001-05-01), None
Ngo et al. (1990). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston.
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry 29:8509-8517.
Clapham et al. (2001). The TRP ion channel family. Nature Reviews Neuroscience 2:387-396.
Jordt et al. (2000). Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl. Acad. Sci., USA 97(14):8134-8139.
Welch et al. (2000). The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc. Natl. Acad. Sci., USA 97(25):13889-13894.
Benham et al. (2003). TRPV channels as temperature sensors. Cell Calcium. 33:479-487.
Smith et al. (2002). TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 418:186-190.
Bevan et al., “Capsazepine: A Competitive Antagonist of the Sensory Neurone Excitant Capsaicin”,Br. J. Pharmacol., (1992) 107:544-552.
S. Bevan and J. Szolcsanyi, “Sensory Neuron-Specific Actions of Capsaicin: Mechanisms and Applications”,TiPS(Aug. 1990) vol. 11.
Caterina et al., “A Capsaicin-Receptor Homologue with a High Threshold for Noxious Heat”,Letters to Nature, (1999) 398.
P. D. Gupta and K. Pushkala, “Importance of the Role of Calcium in Programmed Cell Death: A Review”,Cytobios(1999) 99:83-95.
Leeman et al., “Substance P and Related Peptides: Cellular and Molecular Physiology”,Ann. N.Y. Academy of Sciences, (1991) 632.
B. Minke and Z. Selinger, “The Roles of TRP and Calcium in Regulating Photoreceptor Function in Drosophila”,Neurobiology(1996) 6:459-466.
Oh et al., “Capsaicin Activates a Nonselective Cation Channel in Cultured Neonatal Rat Dorsal Root Ganglion Neurons”,J. Neurosciences, (1996) 16(5): 1659-1667.
M. D. Szallasi, “ARPAD: Autoradiographic Visualization and Pharmacological Characterization of Vanilloid (Capsaicin) Receptors in Several Species Including Man”,ACTA Physiologica Scandinavica, (1995) Supplement. 629, Stockholm, Sweden.
J. Szolcsanyi, “Capsaicin-Sensitive Sensory Nerve Terminals with Local and Systemic Efferent Functions: Facts and Scopes of an Unorthodox Neuroregulatory Mechanism”,Progress in Brain Research, (1996) 113.
Tominaga et al., “The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli”,Neuron(1998) 21:531-543.
Wood et al., “Capsaicin-Induced Ion Fluxes in Dorsal Root Ganglion Cells in Culture”,J. Neuroscience(1988) 8(9): 3206-3220.
Barry, “JPCalc, A Software Package For Calculating Liquid Junction Potential Corrections In Patch-Clamp, Intracellular, Epithelial And Bilayer Measurements And For Correcting Junction Potential Measurements”,J. Neurosci. Methods, vol. 51, pp. 107-116 (1994).
Blackstone et al, “Protein Targeting And Calcium Signaling Microdomains In Neuronal Cells”,Cell Calcium, vol. 26(5), pp. 181-192 (1999).
Caterina et al., “The Capsaicin Receptor: A Heat-Activated Ion Channel In The Pain Pathway”,Nature, vol. 389, pp. 816-824 (1997).
Dubin et al., “Lysophosphatidic Acid Stimulates Neurotransmitter-Like Conductance Changes That Precede GABA And L-glutamate In Early, Presumptive Cortical Neuroblasts”,J. Neurosci., vol. 19(4), pp. 1371-1381 (1999).
Ecker et al., “Increasing Gene Expression In Yeast By Fusion To Ubiquitin”,J. Biol. Chem., vol. 264(13), pp. 7715-7719 (1989).
Horowitz et al., “Synthesis And Assembly Of Functional Mammalian Na, K-ATPase In Yeast”,J. Biol. Chem., vol. 265(8), pp. 4189-4192 (1990).
Jacobson et al., “Expression And Secretion Of Biologically Active Echistatin In Saccharomyces cerevisiae”,Gene, vol. 85, pp. 511-516 (1989).
Kaufman et al., “Amplification And Expression Of Sequences Contransfected With A Modular Dihydrofolate Reductase Complementary DNA Gene”,J. Mol. Biol., vol. 159, pp. 601-621 (1982).
Kitts et al., “Linearization Of Baculovirus DNA Enhances The Recovery Of Recombinant Virus Expression Vectors”,Nucleic Acids Res., vol. 18(19), pp. 5667-5672 (1990).
Kohler et al., “Continuous Cultures Of Fused Cells Secreting Antibody Of Predefined Specificity”,Nature, vol. 256, pp. 495-497 (1975).
Lu et al., “A DNA Deletion Associated With Multiple Impaired Transcripts In The Visual Mutant TRP”,Invest. Ophthalmol. Visual Sci., vol. 28, pp. 2092-2095 (1987).
Luo et al., “Gene Expression Profiles Of Laser-Captured Adjacent Neuronal Subtypes”,Nat. Med., vol. 5(1), pp. 117-121 (1999).
McDonnell et al., “Reconstitution Of The Vitamin D-Responsive Osteocalcin Transcription Unit In Saccharomyces cerevisiae”,Mol. Cell. Biol., vol. 9(8), pp. 3517-3523 (1989).
Mikayama et al., “Molecular Cloning And Functional Expresison Of A cDNA Encoding Glycosylation-Inhibiting Factor”,Proc. Natl. Acad. Sci. USA, vol. 90, pp. 10056-10060 (1993).
Minke et al., “The Roles Of trp And Calcium In Regulating Photoreceptor Function In Drosophila”,Curr. Opin. Neurobiol, vol. 6(4), pp. 459-466 (1996).
Riehl-Bellon et al., “Purification And Biochemical Characterization Of Recombinandt Hirudin Produced By Saccharomyces cerevisiae”,Biochemistry, vol. 28, pp. 2941-2949 (1989).
Rinas et al., “Characterization of Recombinant Factor XIIIa Produced In Saccharomyces Cerevisiae”,Biotechnology, vol. 8, pp. 534-545 (1990).
Sabin et al., “High-Level Expression And in Vivo Processing Of Chimeric Ubiquitin Fusion Proteins In Saccharomyces Cerivisiae”,Biotechnology, vol. 7, pp. 705-709 (1989).
Siekevitz et al., “Activation Of The HIV-1 LTR By T Cell Mitogens And The Trans-Activator Protein Of HTLV-I”,Science, vol. 238(4833), pp. 1575-1578 (1987).
Sleep et al., “The Secretion Of Human Serum Albumin From The Yeast Saccharomyces Cerevisiae Using Five Different Leader Sequences”,Biotechnology, vol. 8, pp. 42-46 (1990).
Suzuki et al., “Cloning Of A Stretch-Inhibitable Nonselective Cation Channel”,J. Biol. Chem., vol. 274(10), pp. 6330-6335 (1999).
Szolcsanyi, “Actions Of Capsaicin On Sensory Receptors”,Capsaicin In The Study Of Pain(Wood, ed.), Academic Press, London; UK, pp. 1-26 (1993).
Szolcsanyi, “Resiniferatoxin. An Ultrapotent Neurotoxin Of Capsaicin-Sensitive Primary Afferent Neurons”,Ann. N. Y. Acad. Sci., vol. 632, pp. 473-475 (1991).
Van Haasteren et al., “Calcium Signaling And Gene Expression”,J. Recept. Signal Transduction Res., vol. 19(1-4), pp. 481-492 (1999).
Voet et al.,Biochemistry, John Wiley & Sons, pp. 126-128 and 228-234 (1990).
Wigler et al., “Transfer Of Purified Herpes Virus Thymidine Kinase Gene To Cultured Mouse Cells”,Cell, vol. 11, pp. 223-232 (1977).
Yamamoto et al., “Important Role Of The Proline Residue In The Signal Sequence That Directs The Secretion Of Human Lysozyme In Saccharomyces cerevisiae”,Biochemistry, vol. 28, pp. 2728-2732 (1989).
Lietdtke et al., “Vanilloid Receptor-Related Osmotically Activated Channel (VR-OAC), a Candidate

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human vanilloid receptor VR3 protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human vanilloid receptor VR3 protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human vanilloid receptor VR3 protein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3678816

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.