Human uterine tissue plasminogen activator produced by recombina

Details Human uterine tissue plasminogen activator produced by recombina Human uterine tissue plasminogen activator produced by recombina

1985-10-01

1994-09-06

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 4352402, 43525421, 4353201, 536 232, 536 235, C12N 964, C12N 1558, A61K 37547

Patent

active

053447735

ABSTRACT:
A replicable expression vector capable, in a transformed host mammallian cell, of expressing a DNA sequence encoding active human TPA which, when expressed in the host cell, yields active TPA which lacks one or more of the TPA-bound N-linked carbohydrate moieties of naturally occurring human TPA.

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Vehar, G. A. et al., Biotechnology, vol. 2, Dec. 1984, pp. 1051-1057, "Characterization Studies on Human Melanoma Cell Tissue Plasminogen Activator".
Little et al., Biochemistry, vol. 23, pp. 6191-6195, Dec. 4, 1984.
Van Zonneveld, et al., J. Cell. Biochemistry, pp. 169-178, 1986.
Tor Ny et al., Proc. Natl. Acad. Sci., vol. 81, pp. 5355-5359, (Sep. 1984).
Rijken (1979) Biochem. Biophys. Acta. 580, 140.

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