Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1983-12-20
1985-11-12
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Lymphokine
A61K 39145
Patent
active
045527580
ABSTRACT:
A method of producing a live attenuated vaccine useful in humans which comprises producing an influenza A reassortant virus by gene exchange between an avian influenza virus parent and a human influenza virus parent and then excluding the internal genes (that code for non-surface viral proteins) of the human influenza virus parent from the reassortant by temperature selection and excluding the surface antigen genes of the avian influenza A virus parent by antibodies.
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Murphy et al., Infection and Immunity, 37:1119-1126, Sep. 1982.
Murphy et al., Science, 218:1330-1332, Dec. 24, 1982.
Hinshaw et al., CA. 99#118900r (1983) Virology 1983 128(1): 260-263, Altered Tissue Tropism of Human-Avian Reassortant Influenza Virises.
Kim et al., CA. 87#148423g, (1977) 12v. Akad. Navk. Kaz. SSR, Ser. Biog. 1977, 15(4): 29-35, Effect of Physiochemical Factors on the Enzymic Activity of Influenza Virus From Man and Birds and Their Recombinants.
Pod Chernyaeva CA. 92#211651d (1980).
Chanock Robert M.
Hinshaw Virginia S.
Murphy Brian R.
Webster Robert G.
Roberts, Jr. John S.
Rose Shep K.
St. Jude Children's Research Hospital
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