Human urotensin II

Details Human urotensin II Human urotensin II

1998-02-20

2000-06-13

Priebe, Scott D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 235, C07H 2100, C12N 1516

Patent

active

060751371

ABSTRACT:
Human Urotensin II polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human Urotensin II polypeptides and polynucleotides in therapy, and diagnostic assays for such.

REFERENCES:
Conlon et al. "Somatostatin- and urotensin II-related peptides molecular diversity and evolutionary perspectives", Regulatory Peptides, vol. 69, pp. 95-103 (1997).
McMaster et al. "Characterization of the Biologically and Antigenically Important Regions of Urotensin II", Proceedings of the Western Pharmacology Society, vol. 29, pp. 205-208 (1986).
Perkins et al. "Molecular modelling and design of analogues of the peptide hormone urotensin II", Biochemical Society Transactions, vol. 18, pp. 918-919 (1990).
Conlon et al. Distribution and Molecular Forms of Urotensin II and Its Role in Cardiovascular Regulation in Vertebrates, The Journal of Experimental Zoology, vol. 275, pp. 226-238 (1996).
Itoh et al. "Functional receptors for fish neuropeptide urotensin II in major rat arteries", European Journal of Pharmacology, vol. 149, pp. 61-66 (1988).
Coulouarn et al "Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord", Proceedings of the National Academy of Sciences of the U.S.A., vol. 95, pp. 15803-15808 (1998).
Orkin et al., "Report and recommendations of the panel to assess the NIH investment in research on gene therapy", issued by the U.S. National Institutes of Health, Dec. 1995.
Ngo et al., "Computational complexity, protein structure prediction, and the Levinthal paradox", in `The Protein Folding Problem and Tertiary Structure Prediction`, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 & 492-495, 1994.
Rudinger, "Characteristics of the amino acid as components of a peptide hormone sequence", in Peptide Hormones, Parsons (ed.), University Park Press: Baltimore, MD, pp. 1-7, Jun. 1976.
GenBank Accession # AA535545, US National Library of Medicine, Aug. 21, 1997.
GenBank Accession # Z98884, US National Library of Medicine, Oct. 29, 1997.

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