Human urinary thrombomodulin with a modified glycosaminoglycan (

Details Human urinary thrombomodulin with a modified glycosaminoglycan ( Human urinary thrombomodulin with a modified glycosaminoglycan (

1993-02-08

1993-12-28

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530380, 530381, 514 2, 435 691, 435 693, C07K 1300, A61K 3702, C12N 1512, C12N 1515

Patent

active

052739627

ABSTRACT:
Recombinant thrombin-binding substances, derived from thrombomodulin by modification of the c-terminal glycosaminoglycan (GAG) binding site and capable of promoting anti-thrombin III activity and inhibiting platelet aggregation, and by themselves possessing anti-thrombin activity are disclosed. The thrombin-binding substances are useful as an effective component of anticoagulant agents, and can be produced inexpensively in a large scale.

REFERENCES:
Suzuki, K., et al. (1989) J. Biol. Chem. 264:4872-76.
Preissner, K. T., et al. (1990) J. Biol. Chem. 265:4915-22.
Nawa, K., et al. (1990) Biochem. Biophys. Res. Comm. 171:729-37.
Jackman, R. W., et al. (1987) Proc. Natl. Acad Sci. USA 84:6425-29.
Parkinson, J. F., et al. (1990) Biochem. Biophys. Res. Comm. 169:177-83.
Bourdon, M. A., et al. (1986) J. Biol. Chem. 261:12534-37.

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