Human ubiquitin-conjugating enzymes

Details Human ubiquitin-conjugating enzymes Human ubiquitin-conjugating enzymes

1997-11-06

2000-01-18

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4352523, 4353201, 536 232, C12N 910, C12N 120, C12N 1500, C07H 2104

Patent

active

06015702&

ABSTRACT:
The invention provides a human ubiquitin-conjugating enzyme (HUBI) and polynucleotides which identify and encode HUBI. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HUBI.

REFERENCES:
Verma, R. et al., "Phosphorylation of Siclp by G.sub.1 Cdk Required for Its Degradation and Entry into S Phase" Science (1997) 278:455-460.
Ciechanover, Aaron, "The Ubiquitin-Proteasome Proteolytic Pathway" Cell (1994) 79:13-21.
Jentsch, Stefan, "The Ubiquitin-Conjugating System," Annu. Rev. Genet. (1992) 26:179-207.
Monia, B.P. et al., "Gene Synthesis, Expression, and Processing of Human Ubiquitin Carboxyl Extension Proteins." J.Biol.Chem. (1989) 264:4093-4103.
van Nocker, S. et al., "The Arabidopsis Thaliana UBC7/13/14 Genes Encode a Family of Multiubiquitin Chain-forming E2 Enzymes." J.Biol.Chem. (1996) 271:12150-12158.
Llovera, M. et al., "Muscle Wasting Associated With Cancer Cachexia is Linked to an Important Activation of the ATP-Dependent Ubiquitin-Mediated Proteolysis" Int.J.Cancer (1995) 61:138-141.
Gregori, L. et al., "Ubiquitin-Mediated Degradative Pathway Degrades the Extracellular but not the Intracellular form of Amyloid .beta.-Protein Precursor" Biochem.Biophys.Res.Commun. (1994) 203:1731-1738.
Grant, E.P. et al., "Rate of Antigen Degradation by the Ubiquitin-Proteasome Pathway Influences MHC Class I Presentation" J.Immunol. (155:3750-3758).
Kershaw, J., GI 1628097, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Kershaw, J., GI 1628091, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Faye, G.R., GI 4257, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Faye, G.R., GI 4256, GenBank Sequence Database (Accession U39318), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.

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