Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-05-23
1999-11-09
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 4241851, 4241921, C07K 1400, A61K 3900
Patent
active
059816996
ABSTRACT:
The present invention concerns a novel human ubiquitin-conjugating enzyme which is implicated in the ubiquitin-mediated inactivation of cell-cycle regulatory proteins, partucularly p53. The present invention makes available diagnostic and therapeutic assays and reagents for detecting and treating transformed cells, such as may be useful in the detection of cancer. The present invention also provides reagents for altering the normal regulation cell proliferation in untransformed cells, such as by upregulating certain cell-cycle checkpoints, e.g. to protect normal cells against DNA damaging reagents.
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Sequence alignments to--Treier et al (1992) EMBO J. 11:367-372.
Sequence alignments to --Zhen et al (1993) Mol. Cell Biol 13:1371-1377.
Draetta Giulio
Eckstein Jens W.
Rolfe Mark
Achutamurthy Ponnathapura
Arnold Beth E.
Mitotix, Inc.
Vincent Matthew P.
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