Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1998-11-20
1999-11-23
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C12N 910
Patent
active
059898836
ABSTRACT:
The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.
REFERENCES:
patent: 5650313 (1997-07-01), Ni et al.
Gregori, L. et al., "Ubiquitin-Mediated Degradative Pathway Degrades the Extracellular but not the Intracellular Form of Amyloid .beta.-Protein Precursor", Biochem.Biophys.Res.Comm. (1994) 203:1731-1738.
Morishima, M. et al., "Posttranslational Modifications of Tau in Paired Helical Filaments", Dementia (1994) 5:282-288.
Grant, E.P. et al., "Rate of Antigen Degradation by the Ubiquitin-Proteasome Pathway Influences MHC Class I Presentation", J. Immun. (1995) 155:3750-3758.
Gosink, M.M. et al., "Redirecting the specificity of ubiquitination by modifying ubiquitin-conjugating enzymes", Proc.Natl.Acad.Sci.USA (1995) 92:9117-9121.
Barrell, B. et al. (Direct Submission), GenBank Sequence Database (Accession 798905), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Seufer, W. et al., "Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins", EMBO J, (1990) 9(2), 543-550 (Accession X17493).
Auffray C. et al., "H. Sapiens Partial cDNA Sequence; Clone C-2cb12," EMBL Sequence Database, (6(Nov. 1994), Heidelberg, Brd, XP002042018, Accession No. Z44894.
Finley, et al., "Ubiquitination", Annu.Rev.Cell Biol. (1991) 7:25-69.
Scheffner, et al., "Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade", Nature (1995) 81-83.
Nuber, U. et al., "Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5", J.Biol.Chem. (1996) 271:2795-2800.
Prendergast, J.A. et al., "Increased Ubiquitin Expression Suppresses the Cell Cycle Defect Associated with the Yeast Ubiquitin Conjugating Enzyme, CDC34 (UBC3)", J.Biol.Chem. (1995) 270:9347-9352.
Liu, Y. et al., "Intragenic Suppression among CDC34 (UBC3) Mutations Defines a Class of Ubiquitin-Conjugating Catalytic Domains", Mol.Cell.Bio. (1995) 15:5635-5644.
Banerjee A. et al., "Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34", J.Biol.Chem. (1995) 270:26209-26215.
Llovera, M. et al., "Muscle Wasting Associated with Cancer Cachexia is Linked to an Important Activation of the ATP-Dependent Ubiquitin-Mediated Proteolysis", Int.J.Cancer (1995) 61:138-141.
Attaix, D. et al., "Regulation of ATP-ubiquitin-dependent proteolysis in muscle wasting", Reprod.Nutr.Dev. (1994) 34:583-597.
Voisin, L. et al., "Muscle Wasting in a Rat Model of Long-lasting Sepsis Results from the Activation of Lysosomal, CA.sup.2+ -activated, and Ubiquitin-Proteasome Proteolytic Pathways", J.Clin.Invest. (1996) 97:1610-1617.
Au-Young Janice
Goli Surya K.
Hillman Jennifer L.
Slobodyansky Elizabeth
Wax Robert A.
LandOfFree
Human ubiquitin-conjugating enzyme does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human ubiquitin-conjugating enzyme, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human ubiquitin-conjugating enzyme will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1220620