Human tumor necrosis factor receptor-like 2

Details Human tumor necrosis factor receptor-like 2 Human tumor necrosis factor receptor-like 2

1999-06-29

2008-11-04

Kemmerer, Elizabeth C. (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C514S002600

Reexamination Certificate

active

07446169

ABSTRACT:
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

REFERENCES:
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5310662 (1994-05-01), Evans et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5359039 (1994-10-01), Smith et al.
patent: 5395760 (1995-03-01), Smith et al.
patent: 5447851 (1995-09-01), Beutler et al.
patent: 5464938 (1995-11-01), Smith et al.
patent: 5605690 (1997-02-01), Jacobs et al.
patent: 6303336 (2001-10-01), Spear et al.
patent: 2045869 (1991-12-01), None
patent: 0 393 438 (1990-10-01), None
patent: 0 555 880 (1993-08-01), None
patent: 0 585 939 (1994-03-01), None
patent: 0 822 984 (1998-02-01), None
patent: WO 91/02078 (1991-02-01), None
patent: WO 91/09045 (1991-06-01), None
patent: WO 93/20219 (1993-10-01), None
patent: WO 94/09137 (1994-04-01), None
patent: WO 94/13808 (1994-06-01), None
patent: WO 97/04658 (1997-02-01), None
patent: WO 97/06251 (1997-02-01), None
patent: WO 98/25967 (1998-06-01), None
patent: WO 98/51346 (1998-11-01), None
US 5,843,791, 12/1998, Hauptmann et al. (withdrawn)
Murdoch et al., 2000, Blood 95:3032-3043.
Benjamin et al., 1998, Development 125:1591-1598.
Vukicevic et al., 1996, PNAS USA 93:9021-9026.
Massague, 1987, Cell 49:437-438.
Pilbeam et al., 1993, Bone 14:717-720.
Skolnick et al., 2000, Trends in Biotech. 18:34-39.
Bork, 2000, Genome Research 10:398-400.
Doerks et al., 1998, Trends in Genetics 14:248-250.
Smith et al., 1997, Nature Biotechnology 15:1222-1223.
Brenner, 1999, Trends in Genetics 15:132-133.
Bork, 1998, Trends in Genetics 12:425-427.
Adams, M.D., et al., “Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project,”Science 252:1651-1656 (1991).
Adams, M.D., et al., “Sequence identification of 2,375 human brain genes,”Nature 355:632-634 (1992).
Aggarwal, B.B., and Natarajan, K., “Tumor necrosis factors: Developments during the last decade,”Eur. Cytokine Netw. 7:93-124 (May 1996).
Altschul, S.F., et al., “Basic Local Alignment Search Tool,”J. Mol. Biol. 215:403-410 (1990).
Armitage, R.J., “Tumor necrosis factor receptor superfamily members and their ligand,”Curr. Opin. Immunol. 6:407-413 (Jun. 1994).
Ashkenazi, A., et al., “Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin,”Proc. Natl. Acad. Sci. USA 88:10535-10539 (1991).
Baens, M., et al., “Construction and Evaluation of a hncDNA Library of Human 12p Transcribed Sequences Derived from a Somatic Cell Hybrid,”Genomics 16:214-218 (1993).
Banchereau, J., et al., “Long-Term Human B Cell Lines Dependent on Interleukin-4 and Antibody to CD40,”Science 251:70-72 (1991).
Banner, D.W., et al., “Crystal Structure of the Soluble Human 55 kd Receptor-Human TNFB Complex: Implications for the TNF Receptor Activation,”Cell 73: 431-445 (1993).
Baum, P.R., et al., Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34,EMBO J. 13:3992-4001 (Sep. 1994).
Baker, E., et al., “Chromosomal location of the human tumor necrosis factor receptor genes,”Cytogenet. Cell Genet. 57: 117-118 (1991).
Birkeland, M.L., et al., “Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein,”Eur. J. Immunol. 25:926-930 (Apr. 1995).
Camerini, D., et al., “The T Cell Activation Antigen CD27 Is a Member of the Nerve Growth Factor/Tumor Necrosis Factor Receptor Gene Family,”J. Immunol. 147:3165-3169 (1991).
Chang, et al., “Identification of a new member of the steroid receptor superfamily by cloning and sequence analysis,”Biochem. Biophys. Res. Comm. 155:971-977 (1988).
Chinnaiyan, A.M., et al., “Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95,”Science 274:990-992 (1996).
Dürkop, H., et al., “Molecular Cloning and Expression of a New Member of the Nerve Growth Factor Receptor Family That is Characteristic for Hodgkin's Disease,”Cell 68:421-427 (1992).
Engelman, H., et al., “Two Tumor Necrosis Factor-binding Proteins Purified from Human Urine,”J. Biol. Chem. 265:1531-1536 (1990).
Feinstein, E., et al., “The death domain: a module shared by proteins with diverse cellular functions,”TIBS 20342-344 (Sep. 1995).
Gillette-Ferguson, I., and Sidman, C.L., “A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmunelprandgldmice,”Eur. J. Immunol. 24:1181-1185 (May 1994).
Goodwin, R.G., et al., “Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor,”Eur. J. Immunol. 23:2631-2641 (1993).
Gruss, H.-J., et al., “Pleiotropic Effects of the CD30 Ligand on CD30-Expressing Cells and Lymphoma Cell Lines,”Blood 83:2045-2056 (Apr. 1994).
Himmler, A., et al., “Molecular Cloning and Expression of Human and Rat Tumor Necrosis Factor Receptor Chain (p60) and Its Soluble Derivative, Tumor Necrosis Factor-Binding Protein,”DNA and Cell Biol. 9:705-715 (1990).
Hohmann, H.-P., et al., “Two Different Cell Types Have Different Major Receptors for Human Tumor Necrosis Factor (TNF∝),”J. Biol. Chem. 264:14927-14934 (1989).
Howard, S.T., et al., “Vaccinia Virus Homologues of the Shope Fibroma Virus Inverted Terminal Repeat Proteins and a Discontinuous ORF Related to the Tumor Necrosis Factor Receptor Family,”Virol. 180:633-647 (1991).
Hsu, K.C., and Chao, M.V., “Differential Expression and Ligand Binding Properties of Tumor Necrosis Factor Chimeric Mutants,”J. Biol. Chem. 268:16430-16436 (1993).
Hu, F.-Q., et al., “Cowpox Virus Contains Two Copies of an Early Gene Encoding a Soluble Secreted Form of the Type II TNF Receptor,”Virol. 204:343-356 (Oct. 1994).
Inui, S., et al., “Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40,”Eur. J. Immunol. 20:1747-1753 (1990).
Itoh, N., et al., “The Polypeptide Encoded by the cDNA for Human Cell Surface Antigen Fas Can Mediate Apoptosis,”Cell 66:233-243 (1991).
Johnson, D., et al., “Expression and Structure of the Human NGF Receptor,”Cell 47:545-554 (1986).
Kramer, P.H., et al., “Regulation of apoptosis in the immune system,”Curr. Opin. Immunol. 6:279-289 (Apr. 1994).
Kwon, B.S., and Weissman, S.M., “cDNA sequences of two inducible T-cell genes,”Proc. Natl. Acad. Sci. USA 86:1963-1967 (1989).
Kwon, B.S., et al., “Genomic Organization and Chromosomal Localization of the T-Cell Agntigen 4-1BB,”J. Immunol. 152:2256-2262 (Mar. 1994).
Lewis, M., et al., “Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific,”Proc. Natl. Acad. Sci. USA 88:2830-2834 (1991).
Loetscher, H., et al., “Molecular Cloning and Expression of the Human 55 kd Tumor Necrosis Factor Receptor,”Cell 61:351-359 (1990).
Mallett, S., et al., “Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes—a molecule related to nerve growth factor receptor,&#x

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