Human TREK2, a stretch- and arachidonic acid-sensitive K+...

Details Human TREK2, a stretch- and arachidonic acid-sensitive K+... Human TREK2, a stretch- and arachidonic acid-sensitive K+...

2005-11-08

2005-11-08

Kemmerer, Elizabeth (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C514S012200, C424S198100

Reexamination Certificate

active

06962976

ABSTRACT:
This invention relates to a protein including a mammalian K+ channel with two pore domains, designated TREK2, that produces currents whose current-voltage relationship is weakly inward rectifying in high symmetrical K+ conditions. This invention further relates to the isolation and characterization of such protein, as well as a method using TREK2 to identify bioactive compounds having anesthetic properties.

REFERENCES:
patent: 6242217 (2001-06-01), Meadows et al.
Fink et al. A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.□□ EMBO J. 17(12):3297-3308, 1998.
Fink et al. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 15(24): 6854-6862, 1996.
Gu et al. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J Physiol. 539(Pt. 3):657-668, 2002.
Lesage et al. Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol. 279(5):F793-801, 2000.
Lesage et al. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem. 275(37):28398-28405, 2000.
Lesage et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 15(5):1004-1011, 1996.
Maylie et al. Beam me up, Scottie! TREK channels swing both ways. Nat Neurosci. 4(5):457-458, 2001.
Patel et al. A mammalian two pore domain mechano-gates S-like K+ channel. EMBO J. 17(15):4283-4290, 1998.
Patel et al. Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci. 2(5):422-426, 1999.

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