Human transglutaminases

Drug – bio-affecting and body treating compositions – In vivo diagnostic or in vivo test agent which contains an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435193, 536 232, A61K 3851, C12N 910, C07H 2104

Patent

active

059520116

ABSTRACT:
Human prostatic and placental transglutaminases are identified and cloned. The human transglutaminases herein are useful for, inter alia, therapeutic wound repair, closure of skin grafts, stabilizing food preparations, and markers for identifying agents which act as agonists or antagonists of cellular apoptosis.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4686195 (1987-08-01), Mullis et al.
patent: 4769328 (1988-09-01), Murray et al.
patent: 5075227 (1991-12-01), Hagen
Dubbink et al. "Tissue-Specific and androgen-regulated . . . " Biochem J. (1996) 315: pp. 901-908.
Folk, "Transglutaminases", Ann. Rev. Biochem. 49: 517-531 (1980).
Bures et al., "Transglutaminase Activity of Cultured Human Prostatic Epithelium" Biol. Abst. 70:3588 (1980).
Lee et al., "Purification of Human Erthrocyte Transglutaminase by Immunoaffinity Chromatography", Prep. Biochem. 16:321-335 (1986).
Ichinose et al., "Amino Acid Sequence of the A Subunit of Human Factor XIII", Biochem. 25: 6900-6906 (1986).
Grundmann et al., "Characterization of cDNA Coding for Human Factor XIIIa", Proc. Natl. Acad. Sci. USA 83: 8024-8028 (Nov., 1986).
Takahashi et al., "Primary Structure of Blood Coagulation Faction XIIIa (fibrinoligase, transglutaminase) from Human Placenta", Proc. Natl. Acad. Sci. USA 83: 8018-8023 (Nov., 1986).
Ablin et al., "Transglutaminase in the Human Prostate and Seminal Plasma: Identification and Possible Implications", Proc. Am. Assoc. Cancer Res. Annual. Meeting 28:174 (1987).
Ablin et al., "Identification of Transglutaminase in Human Prostate and Seminal Plasma", Fed Proc. 46:1495 (1987).
Ho et al., "Androgen Regulated Prostate Genes: Stuctural Analysis and Regulation", Prog. Clin Biol. Res. 239:125-133, (1987).
Ikura et al., "Amino Acid Sequence of Guinea Pig Liver Transglutaminase from its cDNA Sequence", Biochem. 27:2898-2905 (1988).
Ichinose and Davie, "Characterization of the Gene for the A Subunit of Human Factor XIII (Plasma Transglutaminase), a Blood Coagulation Factor", Proc. Natl. Acad. Sci. USA 85:5829-5833 (Aug. 1988).
Aumuller et al., "Differential Reaction of Secretory and Non-secretory Proteins in Hormone-Treated Dunning Tumor", The Prostate 15:81-94 (1989).
Floyd and Jetten, "Regulation of Type I (Epidermal) Transglutaminase mRNA Levels During Squamous Differentiation: Down Regulation By Retinoids", Mol. Cell. Biol. 9:4846-4851 (Nov., 1989).
Seitz et al., "Immunohistochemistry of Secretory Transglutaminase from Rodent Prostate", Histochemistry 93:525-530 (1990).
Enderle-Schmitt et al., "Specific Proteins of the Prostate" Mammalian Biochem. Abst. 112:95963j (1990).
Phillips et al., "Primary Structure of Keratinocyte Transglutaminase", Proc. Natl. Acad. Sci. USA 87:9333-9337 (Dec. 1990).
Gentile et al., "Isolation and Characterization of cDNA Clones to Mouse Macrophage and Human Endothelial Cell Tissue Transglutaminases"J. Biol. Chem. 1:478-483 (Jan. 5, 1991).
Seitz et al., "Purification and Molecular Characterization of a Secretory Tranglutaminase from Coagulating Gland of the Rat", Biochem. Biophys. Acta 1078:139-146 (1991).
Yamanishi et al., "Molecular Cloning of Human Epidermal Transglutaminase cDNA from Keratinocytes in Culture" Biochem. Biophy. Res. Comm. 175:906-913 (Mar. 19, 1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human transglutaminases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human transglutaminases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human transglutaminases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1508096

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.