Human transglutaminases

Details Human transglutaminases Human transglutaminases

1992-12-30

1996-05-07

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 692, 435193, 4353201, 4352543, 536 232, 536 2434, C07H 2104, C12N 510, C12N 1501, C12N 910

Patent

active

055145795

ABSTRACT:
Human prostatic and placental transglutaminases are identified and cloned. The human transglutaminases herein are useful for, inter alia, therapeutic wound repair, closure of skin grafts, stabilizing food preparations, and markers for identifying agents which act as agonists or antagonists of cellular apoptosis.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4686195 (1987-07-01), Mullis et al.
patent: 4769328 (1988-09-01), Murray et al.
patent: 5075227 (1991-12-01), Hagen
Bures et al., "Transglutaminase Activity of Cultured Human Prostatic Epithelium" Biol. Abst. 70:3588 (1980).
Enderle-Schmitt et al., "Specific Proteins of the Prostate" Mammalian Biochem. Abst. 112:95963j (1990).
Gentile et al., "Isolation and Characterization of cDNA Clones to Mouse Macrophage and Human Endothelial Cell Tissue Transglutaminases" J. Biol. Chem. 1:478-483 (Jan. 5, 1991).
Yamanishi et al., "Molecular Cloning of Human Epidermal Transglutaminase cDNA from Keratinocytes in Culture" Biochem. Biophy. Res. Comm. 175:906-913 (Mar. 19, 1991).
Takahashi et al., "Primary Structure of Blood Coagulation Faction XIIIa (fibrinoligase, transglutaminase) from Human Placenta", Proc. Natl. Acad. Sci. USA 83:8018-8023 (1986).
Ablin et al., "Transglutaminase in the Human Prostate and Seminal Plasma: Identification and Possible Implications", Proc. Am. Assoc. Cancer Res. Annual. Meeting 28: 174 (1987).
Ablin et al., "Identification of Transglutaminase in Human Prostate and Seminal Plasma", Fed. Proc. 46: 1495 (1987).
Ho et al., "Androgen Regulated Prostate Genes: Structural Analysis & Regulation"Prog. Clin Biol. Res. 239:125-133 (1987).
Ikura et al., "Amino Acid Sequence of Guinea Pig Liver Transglutaminase from cDNA Sequence", Biochem. 27: 2898-2905 (1988).
Ichinose and Davie, "Characterization of Gene for the A Subunit of Human Factor XIII (Plasma Transglutaminase), Blood Coagulatin Factor", Proc. Natl. Acad. Sci. USA 85: 5829-583 (1988).
Aumuller et al., "Differential Reaction of Secretory and Non-secratory Proteins in Hormone-Treated Dunning Tumor", The Prostate15: 81-94 (1989).
Floyd and Jetten, "Regulation of Type I (Epidermal) Transglutaminase mRNA Levels During Squamous Differentiation: Down Regulation by Retinoids", Mol. Cell. Biol. 9: 4846-4851 (1989).
Folk, "Transglutaminases", Ann. Rev. Biochem. 49: 517-531 (1980).
Lee et al. "Purification of Human Erythrocyte Transglutaminase by Immunoaffinity Chromatography", Prep. Biochem. 16:321-335 (1986).
Ichinose et al., "Amino Acid Sequence of the A Subunit of Human Factor XIII", Biochem. 25: 6900-6906 (1986).
Grundmann et al., "Characterization of cDNA Coding for Human Factor XIIIa" Proc. Natl. Acad. Sci. USA 83: 8024-8028 (1986).
Phillips et al., "Primary Structure of Keratinocyte Transglutaminase", Proc. Natl. Acad. Sci. USA 87:9333-9337 (Dec., 1990).
Seitz et al., "Immunohistochemistry of Secratory Transglutaminase from Rodent Prostate "Histochemistry 93: 525-530 (1990).
Seitz et al. "Purification and Molecular Characterization of a Secratory Transglutaminase from Coagulating Gland of the Rat", Biochem. Biophys. Acta 1078:139-146 (1991).

Affiliated with

Also associated with

Rating

Human transglutaminases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human transglutaminases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human transglutaminases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1226674