Human transcription factor

Details Human transcription factor Human transcription factor

1998-04-13

1999-12-14

McKelvey, Terry

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1447

Patent

active

060019719

ABSTRACT:
The present invention provides a human transcription factor (HTRAN) and polynucleotides which identify and encode HTRAN. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HTRAN.

REFERENCES:
Caldwell, Yakubutsu Dotai (Xenobiotic Metabolism and Disposition), vol. 11(1): pp. 119-125, 1996.
Perkins, A., et al., "Lethal .alpha.-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF," Nature, 375:318-322 (1995).
Pritchard-Jones, K., et al., "The candidate Wilm's tumour gene is involved in genitourinary development," Nature, 346:194-197 (1990).
Kreidberg, J., et al., "WT-1 is Required for Early Kidney Development," Cell, 74:679-691 (1993).
Orkin, S. (GI 1244514; GI 1244515) GenBank Sequence Database (Accession U36340), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Sogawa, K., et al., "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2," Nucleic Acids Research, 21(7):1527-1532 (1993) (GI 303596; GI 303597).
Crossley, M., et al., "Isolation and Characterization of the cDNA Encoding BKLF/TEF-2, a Major CACCC-Box-Binding Protein in Erythroid Cells and Selected Other Cells," Molecular and Cellular Biology, 16(4):1695-1705 (1996).

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