Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Statutory Invention Registration
2007-02-06
2007-02-06
Carone, Michael J. (Department: 3641)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
Statutory Invention Registration
active
07663244
ABSTRACT:
A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
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Goeddel David V.
Kohr William J.
Levinson Arthur D.
Pennica Diane
Simonsen Christian C.
Burns Doane Swecker & Mathis L.L.P.
Genentech Inc.
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