Human tissue-type plasminogen activator variant

Details Human tissue-type plasminogen activator variant Human tissue-type plasminogen activator variant

1990-09-10

1996-12-31

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435226, 4352402, A61K 3849, C12N 1558

Patent

active

055893619

ABSTRACT:
Novel human tissue-type plasminogen activator variant that a) retains substantially full biological activity b) has a modified carbohydrate structure and c) has an altered in vivo half-life. Means for preparation of the variants and results of assays measuring function of the activators are also disclosed.

REFERENCES:
patent: 4753879 (1988-06-01), Rosa et al.
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 5002887 (1991-03-01), Larsen
patent: 5071972 (1991-12-01), Larsen
patent: 5073494 (1991-12-01), Heyneker
patent: 5106741 (1992-04-01), Marotti et al.
patent: 5344773 (1994-06-01), Wei et al.
van Zonneveld, A. et al., PNAS, 83:4670-74, Jul. 1986.
Pennica, D. et al, Nature, vol. 301, pp. 214-221, 1983.
Pohl, et al, Biochemistry, vol. 23, pp. 3701-3707, 1984.
Zoller, et al, Nuc Acids Res, vol. 10, pp. 6487-6500, 1982.
Tate, K. et al, Biochemistry, vol. 26, pp. 338-343, Jan., 1987.
Little et al. (Biochemistry 23, 6191 (1984).

Affiliated with

Also associated with

Rating

Human tissue-type plasminogen activator variant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human tissue-type plasminogen activator variant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human tissue-type plasminogen activator variant will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1141415