Human tissue-type plasminogen activator variant

Details Human tissue-type plasminogen activator variant Human tissue-type plasminogen activator variant

1995-06-01

1998-02-03

Jagannathan, Vasu S.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435226, A61K 3849, C07K 14435, C12N 948

Patent

active

057141444

ABSTRACT:
Novel human tissue-type plasminogen activator variant that a) retains substantially full biological activity b) has a modified carbohydrate structure and c) has an altered in vivo half-life. Means for preparation of the variants and results of assays measuring function of the activators are also disclosed.

REFERENCES:
patent: 4753879 (1988-06-01), Rosa et al.
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 5002887 (1991-03-01), Larsen
patent: 5071972 (1991-12-01), Larsen
patent: 5073494 (1991-12-01), Heyneker
patent: 5106741 (1992-04-01), Marotti et al.
patent: 5344773 (1994-09-01), Wei
Lemontt, J., et al., DNA, 1(6):419-428 (1985).
Berman, P., et al., Trends in Biotechnology, 3;51-53 (1985).
Little, S., et al., Biochemistry, 23:6191-6195 (1984).
Pohl, G., et al., Biochemistry, 23:3701-3707 (1984).
Zoller, M., et al., Nuc. Acids Res., 10:6187-6500 (1982).
Pennica, D., et al., Nature, 301:214-221 (1983).
Tate, K., et al, Biochemistry, 26:338-343 (1987).
Van Zonneveld, A., et al., PNAS, 83:4670-4674 (1986).
Gottlieb, C., et al., J. Biol. Chem., 250(9):3303-3309 (1975).
Stanley, P., Methods in Enzymology, 96:157-163 (1983).
Stanley, P., Ann. Rev. Genet., 18:525-552 (1984).
Stanley, P., Molecular and Cellular Biology, 9(2):377-383.
Trimble, R.B. et al. Analytical Biochemistry 141:515-522 (1984).

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