Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1992-02-19
1994-05-24
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351723, 435212, C12N 1558, C12N 1500
Patent
active
053148185
ABSTRACT:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
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Zoller et al., Methods in Enzymology, vol. 154, Part E, 329-350 (1987).
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Anderson Stephen P.
Higgins Deborah L.
Hotchkiss Adair J.
Marks Cara B.
Dreger Walter H.
Genentech Inc.
Schwartz Richard A.
Vogel Nancy T.
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