Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1994-07-18
1998-06-23
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435212, 435215, C12N 964, C12N 948, C12N 972
Patent
active
057704252
ABSTRACT:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.
REFERENCES:
patent: 4935237 (1990-06-01), Higgins et al.
Tate, et al., Biochemistry 26 (2), 338-343 (1987).
Higgins, et al. Thrombosis and Haemostatis 58 (1), 287 (1987) Abstract 1043.
Kagitani, et al. Febs Letters 189 (1), 145-149 (1985).
Hansen, et al. Journal of Biological Chemistry 263 (30), 15713-15719 (1988).
Harris, Protein Engineering vol. 1, 449-458 (1987).
Van Zonneveld et al., J. Biol. Chem. vol. 261 (30), 14214-14218 (1986).
Zoller et al., Methods in Enzymology, vol. 154, Part E., 329-350 (1987).
Anderson Stephen P.
Higgins Deborah L.
Hotchkiss Adair J.
Marks Cara B.
Dreger Walter H.
Genentech Inc.
Railey II Johnny F.
LandOfFree
Human tissue plasminogen activator variants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human tissue plasminogen activator variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human tissue plasminogen activator variants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1393664