Human tissue plasminogen activator variant

Details Human tissue plasminogen activator variant Human tissue plasminogen activator variant

1993-02-11

1994-11-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4351723, 435212, 435215, C12N 964, C12N 1500, C12N 948, C12N 972

Patent

active

053668863

ABSTRACT:
Disclosed are novel variants of tissue plasminogen activator (t-PA) that have surprising biological/pharmacokinetic properties compared with native t-PA. For example, certain of the variants hereof demonstrate increased half-life profiles, and show good fibrin binding activity even though fibrin binding regions of the molecule are deleted. All associated means and methods for preparing such variants recombinantly and for using such variants are also disclosed.

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Harris, Protein Engineering vol. 1, 449-458 (1987).
Van Zonneveld et al., J. Biol. Chem. vol. 261 (30), 14214-14218 (1986).
Zoller et al., Methods in Enzymology, vol. 154, Part E., 329-350 (1987).

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