Human tissue plasminogen activator substituted at position 275 o

Details Human tissue plasminogen activator substituted at position 275 o Human tissue plasminogen activator substituted at position 275 o

1990-05-11

1991-12-17

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C12N 964

Patent

active

050734946

ABSTRACT:
Biologically active mutant tissue plasminogen activators are disclosed wherein site directed mutagenesis, for example, of a two-chain activation site renders said mutants resistant to conversion to the two-chain form.

REFERENCES:
patent: 4753879 (1988-06-01), Rosa et al.
Pennica, D. et al., Nature, vol. 301, pp. 214-221, 1983.
Tate, K. et al., Biochemistry, vol. 26, pp. 338-343, Jan. 1987.

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