Human tissue plasminogen activator consisting essentially of t-P

Details Human tissue plasminogen activator consisting essentially of t-P Human tissue plasminogen activator consisting essentially of t-P

1991-05-30

1993-08-10

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9463, 435212, 435226, A61K 37547, A61K 3754

Patent

active

052346862

ABSTRACT:
A purified fibrinolytically active degraded species of tissue-type plasminogen activator comprising a fibrinolytically intact B chain of native t-PA linked to kringle 2 as the only functionally and structurally intact domain of native t-PA A chain.

REFERENCES:
patent: 4853330 (1989-08-01), Goeddel
patent: 4908204 (1990-03-01), Robinson
patent: 4970159 (1990-11-01), Dodd
Dodd, I. et al., Thrombosis and Haemostasis, 59(3):523-28, 1988.
Van Zonneveld A, et al., Thrombosis and Haemostasis, vol. 54, Jul. 15, 1985, Abstract 022.
Van Zonneveld, A. et al., PNAS, vol. 83, pp. 4670-4674 (Jul. 1986).
Pannekoek, H. et al., EMBO Workshop on Plasminogen Activation, Amalfi, Italy, Oct. 14-18, 1985.
Kluft et al., Text of paper presented at EMBO Workshop on Plasmingen Activation, Amalfi, Italy, Oct. 14-18, 1985.
Browne, et al., Thrombosis and Haemostasis, vol. 54(2) 422-424 1985.
Elaine Lynette Wilson et al., Cancer Research 40, 933 (1980).
Pennica, D. et al., 1983, Nature, 301, 214-221.
Rijken, D. C., 1984, Haemostasis, 14, 14.
Huessen, C. and Dowdle, E. B., 1980, Anal. Biochem., 102, 196-202.
Gilbert, L. C. and Wachsman, J. T., 1982, Biochim. Biophys. Acta., 704, 450-460.
Sueishi, K. et al., 1982. Biochim. Biophys. Acta., 717, 327-336.
Ny, T. et al., 1984, Proc. Natl. Acad. Sci. USA 81, 5355.
Korninger et al., Thromb Haemostas (Stuttgart) 46(3) 658-661 (1981).

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