Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-04-22
1999-12-14
Budens, Robert D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
4241391, 4241521, 4241721, 4241781, 435331, 5303879, 53038825, 5303893, C07K 1636, C07K 1646
Patent
active
060019786
ABSTRACT:
DNA segments that include DNA sequences defining a structural gene coding for a human tissue factor heavy chain protein and a precursor form of that protein are disclosed. Recombinant DNA molecules capable of expressing a human tissue factor heavy chain protein are also disclosed. Further disclosed are human tissue factor heavy chain binding site polypeptide analogs as well as methods for their use.
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Carson, et al, "Monoclonal Antibodies Against Bovine Tissue Factor, which Block Interaction with Factor VII", Blood, 66: 152-156 (1985).
Broze, et al, "Purification of Human Brain Tissue Factor", J. Biol. Chem., 260: 10917-10920 (1985).
Bom, et al, "Application of Factor Vii-Sepharose Affinity Chromatography in the Purification of Human Tissue Factor Apoprotein", Thrombosis Research, 42: 635-643 (1986).
Guha, et al, "Affinity Purification of Human Tissue Factor: Interaction of Factor VII and Tissue Factor in Detergent Micelles", Proc. Natl. Acad. Sci., 83: 299-302 (1986).
Edgington Thomas S.
Morrissey James H.
Budens Robert D.
Fitting Thomas
Holmes Emily
The Scripps Research Institute
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