Human TIMP-1 antibodies

Details Human TIMP-1 antibodies Human TIMP-1 antibodies

2006-08-14

2008-10-07

Saunders, David A (Department: 1644)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000, C435S070100

Reexamination Certificate

active

07432364

ABSTRACT:
Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.

REFERENCES:
patent: 5324634 (1994-06-01), Zucker
patent: 5338661 (1994-08-01), Jensenius et al.
patent: 5674754 (1997-10-01), Ahrens et al.
patent: 5877289 (1999-03-01), Thorpe et al.
patent: 6004555 (1999-12-01), Thorpe et al.
patent: 6036955 (2000-03-01), Thorpe et al.
patent: 6093399 (2000-07-01), Thorpe et al.
patent: 8134098 (1996-05-01), None
patent: WO 00/20642 (2000-04-01), None
patent: WO 00/62070 (2000-10-01), None
Rudikoff, S et al. Proc Natl Acad Sci USA [1982] 79:1979-1983.
MacCallum, RM et al. J. Mol. Biol. [1996] 262:732-745.
Casset, F et al. Biochem. Biophys. Res. Comm. [2003] 307:198-205.
Wu, H etal. J. Mol. Biol. [1999] 294:151-162.
Guedez et al., “In Vitro Suppression of Programmed Cell Death of B Cells by Tissue Inhibitor of Metalloproteinases-1”,The Journal of Clinical Investigation, 102(11):2002-2010 (1998).
Holten-Andersen et al., “Characterization of Monoclonal Antibodies to Tissue Ingibitor of Metalloproteinases-1”,Journal of Clinical Ligand Assay25(1):87-90 (2002).
Holten-Andersen et al., “Measurement of the Noncomplexed Free Fraction of Tissue Inhibitor of Metalloproteinases I in Plasma by Immunoassay”,Clinical Chemistry, 48(8):1305-1313 (2002).
Krebs et al., “High-throughput Generation and Engineering of Recombinant Human Antibodies”,Journal of Immunological Methods, 254:67-84 (2001).
Lu et al., “Immunological Quantitation of Levels of Tissue Ingibitor of Metalloproteinase-1 in Human Colon Cancer”,Cancer Research, 51(23):6231-6235 (1991).
Parsons et al., “Antifibrotic Effects of a Tissue Inhibitor of Metalloproteinase-1 Antibody on Established Liver Fibrosis in Rats”,Hepatology, 40(5):1106-1115 (2004).
Paul W.E., editor., “Structure and Function of Immunoglobulins”,Fundamental Immunology, 3rd edition. Raven Press, New York, pp. 292-295 (1993).
Reed et al., “A Deficit on Collagenase Activity Contributes to Impaired Migration of Aged Microvascular Endothelial Cells”,Journal of Cellular Biochemistry, 77:116-126 (2000).
Wozniak et al., “Expression of TIMP-1 inPichia pastoris. Selection of an Anti-TIMP-1 Specific Single-chain Fv Antibody from a Large Non-immune Library”,Clinica Chimica Acta, 327:171-179 (2003).

Affiliated with

Also associated with

Rating

Human TIMP-1 antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human TIMP-1 antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human TIMP-1 antibodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4005637