Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-05-24
1999-02-23
Fitzgerald, David L.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4353723, 435 697, A61K 4505, C12N 522
Patent
active
058740775
ABSTRACT:
Tumor Infiltrating Lymphocyte (TIL) cells transformed with exogenous DNA encoding tumor necrosis factor (TNF) prohormone variants are disclosed. Among such variants are the TNF .gamma. sig construct, which facilitates expression of the mature TNF polypeptide, and the noncleavable cytotoxic prohormone variants TNF.DELTA.(1.fwdarw.12) and TNF(1+12). The transformed TIL cells are useful in antitumor therapy.
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Kriegler Michael
Perez Carl F.
Blackburn Robert P.
Chiron Corporation
Fitzgerald David L.
Kruse Norman J.
Pochopien Donald
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