Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-04-29
2000-01-25
Degen, Nancy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303871, 5303879, 5303881, G01N 3353, C07K 1600
Patent
active
060177179
ABSTRACT:
The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin .beta. family. This novel protein, herein referred to as thymosin .beta.15, has the ability to bind and sequester G-actin, like other members of the thymosin .beta. family, but unlike what is known about other members it also directly regulates cell motility in prostatic carcinoma cells. The present invention is direct to an isolated cDNA encoding the human thymosin .beta.15 gene (SEQ ID NO: 1) and have deduced the amino acid sequence (SEQ ID NO: 2).
REFERENCES:
patent: 5831033 (1998-11-01), Zetter et al.
Nachmiar, V., Current Opinion in Cell Biology, 1993, 5:56.
Safer, et al., Proc. Natl. Acad. Sci USA 1990 87:2536-2540.
Safter, et al., J. Biol. Chem., 1991, 268:4029-4032).
D. Safer, J. Muscle Res. Cell Motil, 1992. 13:269-271).
Weber, et al., Biochemistry 1992, 31:6179-6185).
Yu, et al., J. Biol. Chem., 1993, 268:502-509.
Cassimeris, et al., J. Cell Biol., 1992, 119:1261-1270.
Low, et al., Arch. Biochem. Biophys., 1992, 293:32-39.
Low, et al., Proc. Natl. Acad. Sci., USA 1981, 78:1162-1166.
Rebar, et al., Science 1981, 214:669-671.
Gomez-Marquez, et al., J. Immunol. 1989, 143:2740-2744.
Bao, et al., The American Association for Cancer Research annual meeting (Mar. 18-22, 1995), Abstract.
Clauss, et al., Genomies 1991, 9:75-180.
Sanders, et al., Proc. Natl. Acad. Sci. USA 1992, 89:4678-4682.
Bao, et al., Proceedings of the American Association For Cancer Research, Annual Meeting, vol. 36, p. 85 XP002041934, see abstract A505 (1995).
K. Kwiatowska, et al., Molecular Biology of the Cell, Supplement, vol. 6, p. 141A XP002041935, see abstract 816 (1995).
Sun, et al., J. Bio. Chem., vol. 271, No. 16, pp. 9223-9230 XP002041936 (1996).
S. Varghese, et al., J. Bio. Chem., vol. 266, No. 22, pp. 14256-14261 XP002041937 (1991).
Lin, et al., J. Bio. Chem, vol. 266, No. 35, pp. 23347-23353, XP002041938 (1991).
Bao, et al., Proceedings of the American Association For Cancer Research, Annual Meeting, vol. 38, pp. 492-493, XP002041939 (1997).
B. Zetter, vol. 51, No. 4, p. 185 XP002041940 (1997).
Bao, et al., Nature Medicine, vol. 2, No. 12, pp. 1322-1328 XP002041941 (1996).
D. Coffey, Nature Medicine, vol. 2, No. 12, pp. 1305-1306 XP002041942 (1996).
European Search Report for PCT/US97/10315, mailed Oct. 22, 1997.
Bao Lere
Zetter Bruce R.
Children's Medical Center Corporation
Degen Nancy
Eisenstein Ronald I.
Peabody LLP Nixon
Resnick David S.
LandOfFree
Human thymosin .beta.15 gene, protein and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human thymosin .beta.15 gene, protein and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human thymosin .beta.15 gene, protein and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2314949