Human thrombomodulin in wound healing

Details Human thrombomodulin in wound healing Human thrombomodulin in wound healing

1993-12-03

1996-12-10

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 530350, A61K 3816, A61K 3817, C07K 14435, C07K 1447

Patent

active

055831028

ABSTRACT:
The use of human thrombomodulin and acceptable derivatives thereof as an agent for stimulating wound regeneration including epithilial cell differentiation is disclosed.

REFERENCES:
patent: 4912207 (1990-03-01), Majerus et al.
patent: 5126140 (1992-06-01), Ito et al.
Lentz, Sequences Required for Thrombomodulin Cofactor Activity Within the Fourth Epidermal Growth Factor-Like Domain of Human Thrombomodulin, 1993 Journal of Biological Chemistry, 268:15312-15317.
Carney, The Role of Thrombin and Thrombin Receptor Activating Peptide (Trap-508) in Initiation of Tissue Repair, Thrombosis and Haemostasis 158-162.
Clark, Cutaneous Wound Repair, "Physiology, Biochemistry, and Molecular Biology of the Skin", L. A. Goldsmith, editor, Oxford Press, New York 1991.
McCachren et al. "Thrombomodulin Expression By Human Blood Monocytes and by Human Synovial Tissue Lining Macrophages" Blood 78(12) 3128-3132 1991.

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