Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2006-10-31
2006-10-31
Monshipouri, Maryam (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
C530S350000, C435S194000
Reexamination Certificate
active
07129057
ABSTRACT:
The present invention relates to a family of testis specific kinases (the tssk family), nucleic acid sequences encoding those kinases and antibodies against the kinases. The invention is further directed to the use of thise kinases as targets for isolating specific inhibitors or anagonists of tssk kinase activity. Such inhibitors are anticipated to have use as contraceptive agents.
REFERENCES:
patent: 2003/0211093 (2003-11-01), Yue et al.
patent: 2004/0048249 (2004-03-01), Tang et al.
Visconti, P. E., et al., “Cloning and Chromosomal Localization of a Gene Encoding a Novel Serine/Threonine Kinase Belonging to the Subfamily of Testis-Specific Kinases”, Genomics, 2001, 77:3:163-170.
Toshima, J., et al., “Identification and Characterization of a Novel Protein Kinase, TESK1, Specifically Expressed in Testicular Germ Cells”, Journal of Biological Chemistry, 1995, 270:52:31331-31337.
Herr, J. C., Faculty/Core Leaders University of Virginia, XP002308009 URL:http://web.archive.org/web/20000918171959/hsc.virginia.edu/medicine/basic-sci/cellbio/crgcv/people/jch7k.html>, Oct. 18, 2000, p. 1-2.
Visconti, P. E., et al., “Cholesterol Efflux-Mediated Signal Transduction in Mammalian Sperm: Cholesterol Release Signals an Increase in Protein Tyrosine Phosphorylation during Mouse Sperm Capacitation”, Developmental Biology, 1999, 214:429-443.
De Lamirande, Eve, et al., “Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization”, Molecular Human Reproduction, 1997, 3:3:175-194.
Database Embl, database accession No. AL109945, 1999 Human DNA sequence from clone RP4-811H24 on chromosome 1p34.1-34.3 Contains the 3′ end of LCK gene for lymphocyte-specific protein tyrosine kinase, HDAC1 gene for histone deacetylase 1, the MLP gene for MARCKS-like protein STK22C.
Database Embl, database accession No. AC010431, “Homo sapienschromosome 5 clone CTD-2201G3, complete sequence.” XP002308771, Sep. 17, 1999.
Database Embl, database accession No. AL359537, “Human DNA sequence***Sequencing Cancelled*** from clone RP13-67019” XP002308772, Jun. 18, 2000.
Bielke, W., Blaschke, R. J., Miescher, G. C., Zurcher, G., Andres, A. C., and Ziemiecki, A. (1994). “Characterization of a novel murine testis-specific serine/threonine kinase”. Gene. vol. 139, pp. 235-239.
Kueng, P., Nikolova, Z., Djonov, V., Hemphill, A., Rohrbach, V., Boehlen, D., Zuercher, G., Andres, A. C., and Ziemiecki, A. (1997). “A novel family of serine/threonine kinases participating in spermiogenesis”. J Cell Biol. vol. 139, pp. 1851-1859.
Visconti, P. E., Bailey, J. L., Moore, G. D., Pan, D., Olds-Clarke, P., and Kopf, G. S. (1995a). “Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation”. Development. vol. 121, pp. 1129-1137.
Visconti, P. E., Johnson, L. R., Oyaski, M., Fornes, M., Moss, S. B., Gerton, G. L., and Kopf, G. S. (1997). “Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation”. Dev. Biol. vol. 192, pp. 351-363.
Visconti, P. E., and Kopf, G. S., (1998). “Regulation of protein phosphorylation during sperm capacitation”. Biol. Reprod. vol. 59, pp. 1-6.
Visconti, P.E., Moore, G.D., Bailey, J.L., Leclerc, P., Connors, S.A., Pan, D., Olds-Clarke, P., and Kopf, G. S. (1995b). “Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by cAMP-dependent pathway”. Development. vol. 121, pp. 1139-1150.
Zuercher, G., Rohrbach, V., Andres, A. C., and Ziemiecki; A. (2000). “A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice”. Mech Dev. vol. 93, pp. 175-177.
Database GenEmbl, No. AC010431, Doe Joint Genome Institute and Stanford Human Genome Center. ‘Homo sapienschromosome 5 clone CTD- 2201G3, complete sequence’, Direct Submission, Jun. 8, 2001.
Hao Zhonglin
Herr John C.
Kopf Gregory S.
Visconti Pablo E.
Monshipouri Maryam
Sparks Rodney L.
The Trustees of the University of Pennsylvania
University of Virginia Patent Foundation
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