Human testis specific serine/threonine kinase 1 and 2

Details Human testis specific serine/threonine kinase 1 and 2 Human testis specific serine/threonine kinase 1 and 2

2005-09-20

2005-09-20

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S252300, C435S320100, C435S325000, C530S350000

Reexamination Certificate

active

06946275

ABSTRACT:
The present invention relates to a family of testis specific kinases (the tssk family), nucleic acid sequences encoding those kinases and antibodies against the kinases. The invention is further directed to the use of those kinases as targets for isolating specific inhibitors or antagonists of tssk kinase activity. Such inhibitors are anticipated to have use as contraceptive agents.

REFERENCES:
patent: 6482935 (2002-11-01), Wei et al.
Bielke, W., Blaschke, R. J., Miescher, G. C., Zurcher, G., Andres, A. C., and Ziemiecki, A. (1994). “Characterization of a novel murine testis-specific serine/threonine kinase”. Gene. vol. 139, pp. 235-239.
Kueng, P., Nikolova, z., Djonov, V., Hemphill, A., Rohrbach, V., Boehlen, D., Zuercher, G., Andres, A. C., and Ziemiecki, A. (1997). “A novel family of serine/threonine kinases participating in spermiogenesis”. J Cell Biol. vol. 139, pp. 1851-1859.
Visconti, P. E., Bailey, J. L., Moore, G. D., Pan, D., Olds-Clarke, P., and Kopf, G. S. (1995a). “Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation”. Development. vol. 121, pp. 1129-1137.
Visconti, P. E., Johnson, L. R., Oyaski, M., Fornes, M., Moss, S. B., Gerton, G. L., and Kopf, G. S. (1997). “Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation”. Dev. Biol. vol. 192, pp. 351-363.
Visconti, P. E., and Kopf, G. S., (1998). “Regulation of protein phosphorylation during sperm capacitation”. Biol. Reprod. vol. 59, pp. 1-6.
Visconti, P.E., Moore, G.D., Bailey, J.L., Leclerc, P., Connors, S.A., Pan, D., Olds-Clarke, P., and Kopf, G.S. (1995b). “Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway”. Development. vol. 121, pp. 1139-1150.
Zuercher, G., Rohrbach, V., Andres, A. C., and Ziemiecki, A. (2000). “A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice”. Mech Dev. vol. 93, pp. 175-177.
Database GenEmbl, No. AC010431, Doe Joint Genome Institute and Stanford Human Genome Center. ‘Homo sapienschromosome 5 clone CTD- 2201G3, complete sequence’, Direct Submission, Jun. 8, 2001.

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