Human telomerase gene RNA interacting protein gene

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435194, 4352523, 4353201, 435 911, 435 913, 536 231, 536 232, 536 235, 530350, C12Q 168, C12N 912, C07H 2104, C12P 1934

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active

058887474

ABSTRACT:
The invention provides methods and compositions relating to a human telomerase and related nucleic acids, including four distinct human telomerase subunit proteins called p140, p105, p48 and p43 having human telomerase-specific activity. The proteins may be produced recombinantly from transformed host cells from the disclosed telomerase encoding nucleic acids or purified from human cells. Also included are human telomerase RNA components, as well as specific, functional derivatives thereof. The invention provides isolated telomerase hybridization probes and primers capable of specifically hybridizing with the disclosed telomerase gene, telomerase-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
patent: 5583016 (1996-12-01), Villeponteau et al.
Counter et al. P.N.A.S, USA. 91:2900-2904, 1994.

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