Human T2R63 receptor and related assays for identifying...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007210, C436S501000

Reexamination Certificate

active

07736862

ABSTRACT:
The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R63 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. These compounds may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in foods, beverages and medicinals for blocking bitter taste.

REFERENCES:
patent: 7579453 (2009-08-01), Drayna et al.
patent: 2002/0177576 (2002-11-01), McGregor et al.
patent: 2005/0244810 (2005-11-01), Egan et al.
patent: 2006/0248602 (2006-11-01), Bufe et al.
patent: 2007/0059688 (2007-03-01), Rozengurt
patent: 2007/0128604 (2007-06-01), Drayna et al.
patent: 2008/0213761 (2008-09-01), Bufe et al.
patent: WO 99/42470 (1999-08-01), None
patent: WO 01/18050 (2001-03-01), None
patent: WO 01/77676 (2001-10-01), None
patent: WO 02/16548 (2002-02-01), None
Hoon, et al., Cell, vol. 96, p. 541-551, 1999.
Lindemann, B., Nature Neuroscience, vol. 3, No. 2, p. 99-100, 2000.
Perruccio and Kleinhaus, Society for Neuroscience Abstracts, vol. 26, No. 1-2, Abstract No. 66.15, 2000.
Chandrashekar, et al., Cell, vol. 100, p. 703-711, 2000.
Bowie, et al., Science, vol. 247, p. 1306-1310, 1990.
Alexander, et aql., Proc. Natl. Acad. Sci., vol. 89, p. 3352-3356, 1992.
Brenner, et al., PNAS, vol. 95, p. 6073-6078, 1998.
Guo-HH, et al., PNAS, vol. 101, No. 25, p. 9205-9210, 2004.
Horrobin, DF, British Med. Journal, vol. 322(7280, 239, Jul. 2003.
Lahan, R., Drug Discovery Today, vol. 4, No. 10, p. 447-4478, 1999.
Database EMBL [online] Oct. 11, 1999, B. Biren, et al., “Homo sapiensclone RP11-17E6”, XP002372161 retrieved from EBI Database Accession No. AC011654.
E. Adler et al., “A Novel Family of Mammalian Taste Receptors” Cell, vol. 100, No. 6, p. 693-702 Mar. 17, 2000.
David Smith et al., “Taste Processing: Whetting our Appetites”, Current Biology, vol. 9, No. 12, p. R453-R455, Jun. 17, 1999.
Peter Mombaerts, “Molecular Biology of Odorant Receptors in Vertebrates”, USA Series: Annual Review of Neuroscience (ISSN 0147-006X), 1999, p. 487-509.
Altschul et al., Basic Local Alignment Search Tool, J Mol. Biol., vol. 215, pp. 403-410, 1990.
Altschul et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol. 25, No. 17, pp. 3389-3402, 1977.
Henikoff et al., Amino acid substitution matrices from protein blocks, Proc. Natl. Acad. Sci., vol. 89, pp. 10915-10919, 1992.
Rose et al., Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences, Nucleic Acids Research, vol. 26, No. 7, pp. 1628-1635, 1998.
Singh et al., Primer Premier: Program for Design of Degenerate Primers from a Protein Sequence, BioTechniques, vol. 24, No. 2, pp. 318-319, 1998.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Human T2R63 receptor and related assays for identifying... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human T2R63 receptor and related assays for identifying..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human T2R63 receptor and related assays for identifying... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4215580

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.