Human t-PA production using vectors coding for DHFR protein

Details Human t-PA production using vectors coding for DHFR protein Human t-PA production using vectors coding for DHFR protein

1991-02-28

1993-12-07

Martinell,, James

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 435 692, C12N 510, C12N 516, C12P 2102

Patent

active

052682919

ABSTRACT:
A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.

REFERENCES:
patent: 5010002 (1991-04-01), Levinson et al.
patent: 5011795 (1991-04-01), Levinson et al.
Ringold et al.; J. Mol. Appl. Genet. 1: 165 (1981).

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