Human T or B cell lines and a process for producing immunologica

Details Human T or B cell lines and a process for producing immunologica Human T or B cell lines and a process for producing immunologica

1985-05-21

1988-07-19

Weimar, Elizabeth

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4352402, 435948, C12N 500, C12P 2100, C12R 191

Patent

active

047585137

ABSTRACT:
This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immunologically active substance comprising culturing a human B- or T- cell line carrying at least one human Ela adenovirus 12-type gene or fragment thereof in a culture medium capable of supporting growth thereof for a period of time effective to attain a spontaneous production of the substance thereof.

REFERENCES:
patent: 4560655 (1985-12-01), Baker
Takahashi et al., "Protein Synthesis in the Cells Transformed by Ela Gene of Adenovirus Type 12"; Growth Differ. Cells Defined Environ. Proc. Int. Symp. 1984, Pub. 1985, pp. 425-427.
Takahashi et al. Chem Abstracts 104:222739c 1986.
Takahashi et al. Chem Abstracts 103:17737p 1985.
Shiroki et al. J. Virol 45(3): 1074-82 1983.
Eager et al. Proc Natl Acad Sci USA 82:5525-5529 1985.
Schrier et al. Nature 305:771-775 1983.
Weeks et al. Molec Cell Biol 3(7):1222-1234 1983.
Pelham Cell 30:517-528 1982.

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