Human T cell reactive feline protein (TRFP) isolated from house

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4242751, 435 71, 435 721, 436 63, A61K 3900, A61K 3935, G01N 3353, G01N 33567

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active

061207691

ABSTRACT:
A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.

REFERENCES:
patent: 4163778 (1979-08-01), Ohman
Kumar et al. PNAS 87:1337-41, Feb. 1990.
Salgaller et al. Cancer Immunol. Immunother. 39:105-116, 1994.
Lazar et al. Mol. Cell Biology 8(3):1247-1252, Mar. 1988.
Burgess et al. J. Cell Biol. 111: 2129-38, Nov. 1990.
Anderson, et al., "A Comparative Study of the allergens of cat urine . . . ", J. Aller. Clin. Immunol., (Oct., 1985), 76(4):563-569.
de Groot, et al., "Monoclonal antibodies to the major feline allergen Fel d l", J. Aller. Clin. Immunol., (Nov., 1987), 82(5):778-786.
Didierlaurent, et al., "Comparative Study on Cat Allergens from Fur and Saliva", Int. Archs Allergy appl. Immunul., (1984), 73:27-31.
Chapman, et al, "Monoclonal Antibodies to the Major Feline Allergen Fel d l", The Journal of Immunol., (1987), 140(3): 812-818.
Duffort, et al., "Characterization of the Main IgE-Binding Components of Cat Dander", Int. Archs Allergy Appl. Immunol., (1987), 84:339-344.
Duffort, et al., "Monoclonal antibodies against Fel d I and other clinically relevant cat allergens", Immunology Letters, (1988), 17:71-77.
Jenkins, et al., "Antigen Presentation by Chemically Modified Splenocytes . . . ", Journal of Experimental Medicine, (Feb. 1987), 165:302-319.
Leitermann, et al., "Cat allergen 1: Biochemical, antigenic, and allergenic properties", (1983), J. Allergy Clin. Immunol., 74(2): 147-153.
Lerner, Richard, "Tapping the immunological repertoire to produce antibodies of predetermined specificity", Nature, (Oct. 1982), 299: 592-596.
Lowenstein, et al., "Identification and Clinical Significance of Allergenic Molecules of Cat Origin", Allergy, (1985), 40:430-441.
Mester and Rouse, "The Mouse Model and Understanding Immunity to Herpes Simplex Virus", Reviews of Infectious Diseases, (1991), 13(Supp. 11): S935-945.
Ohman, et al., "Allergens of Mammalian Origin . . . ", The Journal of Immunol., (Dec. 1984), 113(6): 1668-1677.
Ohman, et al., "Immunotherapy in cat-induced asthma, Double-blind trial with evaluation of in vivo and in vitro responses", J. Allergy Clin. Immunol., (Sep. 1984), 74(3):230-239.
Sundin, et al., "Immunotherapy with partially purified and standardized animal dander extracts", J. Allergy Clin. Immunol., (Mar. 1986), 77(3): 478-487.
van Milligen, et al., "IgE Epitopes on the cat allergen Fel d 1: A Study with Overlapping Synthetic Peptides", CLB and Lab Exp. Clin. Immunol., Univ of Amsterdam, Abstracts, 89(1)part 2: 243.
Pongor, et al., Methods in Enzymology, (1987), 154:450-473.
Stone, et al., Enzymatic Digestion of Proteins & HPLC Peptide Isolation, (1989), pp. 31-47
Young, et al., PNAS, (1983), 80:1194-1198.
Ununue, Textbook of Immunology, 2nd Edition, (1984), chapter 14, pp. 281-298.
Margalit, et al., J. Immunol., (1987), 138(7):2213-2219.

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