Human T cell lines and method of producing same

Details Human T cell lines and method of producing same Human T cell lines and method of producing same

1982-06-02

1985-10-01

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4351721, 4351722, 435242, 435948, 935101, 935109, C12P 2100, C12N 1500, C12N 500, C12R 191

Patent

active

045446326

ABSTRACT:
This invention provides a human parental T cell line which can fuse with normal human T cells, and hybrid cell lines which are prepared by fusion of the human parental T cells and the human T cells, and which are capable of producing lymphokines. This invention also provides methods of obtaining such human T cell lines, and a method of producing lymphokines from such hybrid cell lines.

REFERENCES:
patent: 4401756 (1983-08-01), Gillis
patent: 4407945 (1983-10-01), Gillis
patent: 4434230 (1984-02-01), Ritts, Jr.
patent: 4451570 (1984-05-01), Royston
Szybalski et al., "Genetics of Human Cell Lines I, 8-Azaguanine Resistance, A Selective Single-Step Marker", Proc. Soc. Exp. Biol. Med. 101, pp. 662-666 (1959).
Okada et al., "Establishment and Characterization of Human T Hybrid Cells Secreting Immunoregulatory Molecules", Proceedings of the National Academy of Sciences 78(12) (1981), pp. 7717-7721.
Irigoyen et al., "Generation of Functional Human T Cell Hybrids," Journal of Experimental Medicine 154 (1981), pp. 1827-1837.
Mier et al., "Purification and Some Characteristics of Human T-Cell Growth Factor from PHA-Stimulated Lymphocyte Conditioned Media", Proceedings of the National Academy of Sciences 77(10) (1980, pp. 6134-6138.
Maher et al., "Comparison of the Mutagenic Effect of UV Radiation and Chemicals in Normal and DNA-Repair Deficient Cells," Chemical Mutagens vol. 6 (1980), pp. 309-317.
Olsson et al., "Human Human Hybridomas Producing Monoclonal Antibodies of Predefined Antigenic Specificity," Proceedings of the National Academy of Sciences 77(9) (1980), pp. 5429-5431.
Harwell et al., "Concanavalin A-Inducible Interleukin-2-Producing T-Cell Hybridoma," Journal of Experimental Medicine 152 (1980), pp. 893-904.
Stull et al., "Constitutive Production of Interleukin 2 Activity by a T-Cell Hybridoma," Journal of Immunology 126(5) (1981), pp. 1680-1683.
Grillot-Courvalin et al., "Establishment of a Human T-Cell Hybrid Line with Suppressive Activity," Nature, vol. 292 (8-1981), pp. 844-845.

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