Human T-cell leukemia virus transcription modulators and screeni

Details Human T-cell leukemia virus transcription modulators and screeni Human T-cell leukemia virus transcription modulators and screeni

1995-02-03

1997-04-01

Fleischer, Mindy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435243, 536 235, C12P 2106, C12N 100, C12N 510, C12N 1512

Patent

active

056164750

ABSTRACT:
The invention provides methods and compositions relating to the Tax-response Complex-1 (TRC-1) a transcription complex associated with disease, particularly HTLV infection. TRC-1 is composed of novel forms of JunB and a member of a novel protein family called small nuclear factors or SNFs. The expression of these compounds are shown to correlate with cell lineage, activation and infection. SNFs and T-cell specific forms of JunB, find particular use in screening assays for agents or lead compounds for agents useful in the diagnosis, prognosis or treatment of disease, particularly HTLV infection. Nucleic acids encoding SNFs, and SNF-specific binding agents find use in diagnosis and as commercial reagents for the biopharmaceutical industry.

REFERENCES:
Jones et al., "Marek Disease Virus Encodes a Basic-leucine Zipper Gene Resembling the fos/jun Oncogenes that is Highly Expressed in Lymphoblastoid Tumors", Proc. Natl. Acad. Sci. USA 89:4042-4046 (1992).
Nyborg et al., "Binding of Host-cell Factors to DNA Sequences in the Long Terminal Repeat of Human T-cell Leukemia Virus Type I: Implications for Viral Gene Expression", Proc. Natl. Acad. Sci. USA 85:1457-1461 (1988).
Sch utte et al., "jun-B inhibits and c-fos Stimulates the Transforming and Trans-Activating Activities of c-jun", Cell 59:987-997 (1989).

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