Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-02-28
1989-07-18
Warden, Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 68, 436501, 436506, 436536, 436547, C07G 700
Patent
active
048495077
ABSTRACT:
A compound essentially free of compounds of molecular weight above 10,000, the compound characterized in that it is water soluble, it has a molecular weight between about 1,000 and 10,000, it suppresses immunoglobulin synthesis in pokeweed mitogen-stimulated human lymphocytes, it does not inhibit proliferation of human lymphocytes induced by concanavalin A or pokeweed mitogen, it inhibits phytohemmaglutinin-induced proliferation of human T4 cells, and it inhibits IL-2 production of human T4 cells.
REFERENCES:
patent: 4537712 (1985-08-01), Oh
patent: 4665021 (1987-05-01), Schnaper et al.
patent: 4665032 (1987-05-01), Laureuce
Krakauer et al., "Suppression of Polyclonel Immonoglobelin Biosynthesis . . .", Immunology 40, 53-60 (1980).
Wagner Richard
Warden Robert J.
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