Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-10-14
1996-10-08
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4352401, 4352523, 4353201, 536 231, 536 235, 935 11, 935 22, 935 52, 935 66, C12N 1512, C07K 14475
Patent
active
055630480
ABSTRACT:
The Stromal Derived Factor-1.alpha. (SDF-1.alpha.) and Stromal Derived Factor-1.beta. (SDF-1.beta.) polypeptides of the present invention are produced and secreted in pro-B cells, so they may be used for diseases relating to undergrown or abnormal proliferation of hematopoietic cells, neuronal enhancement or depression, immunological enhancement and depression, for example, inflammatory diseases (rheumatoid arthritis, ulcerative colitis etc.), hematopoietic stemcytopenia after bone marrow transplantation, leukocytopenia, thrombocytopenia, B lymphopenia and T lymphopenia after chemotherapy, anemia, infectious diseases, cancer, leukocytosis, AIDS, neurodegenerative diseases (Alzheimer, multiple sclerosis etc.), prevention or treatment of neuronal injury, prevention or treatment of disorder of bone metabolism (osteoporosis etc.) or tissue repair. The DNAs of the present invention may be utilized as important and essential templates in preparing the polypeptides of the present invention which are expected to possess various uses or for diagnosis of and in the treatment of gene diseases.
REFERENCES:
Weissenbach et al, 1980, Proc. Natl. Acad Sci., vol. 77, No. 12, pp. 7152-7156.
Derynck et al. 1990, Biochemistry, vol. 29 pp. 10225-10233.
Nagasawa et al., "Molecular cloning and structure of a pre-B-cell growth-stimulating factor", Proc. Natl. Acad. Sci. USA, vol. 91, pp. 2305-2309, Mar. 1994.
Tashiro et al., "Signal Sequence Trap: A Cloning Strategy for Secreted Proteins and Type I Membrane Proteins", Science, vol. 261, Jul. 30, 1993 pp. 600-603.
Honjo Tasuku
Shirozu Michio
Tada Hideaki
Mertz Prema
Ono Pharmaceutical Co. Ltd.
Walsh Stephen G.
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