Human stem cells and monoclonal antibodies

Details Human stem cells and monoclonal antibodies Human stem cells and monoclonal antibodies

1987-06-01

1990-10-23

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530809, 424 858, C12N 500, C07K 1500, A61K 3900

Patent

active

049652044

ABSTRACT:
Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as therapeutic methods employing the cell suspensions.

REFERENCES:
patent: 4364932 (1982-12-01), Kung
patent: 4364937 (1982-12-01), Kung
patent: 4381292 (1983-04-01), Bieber et al.
patent: 4381295 (1983-04-01), Kung et al.
patent: 4443427 (1984-04-01), Reinherz
patent: 4582797 (1986-04-01), Trowbridge
patent: 4624925 (1986-11-01), Kung
patent: 4710457 (1987-12-01), Dupont
patent: 4714680 (1987-12-01), Civin
Perschel et al., "M7 Cluster Report: CD34," ed. Knapp, et al., at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 817.
Civin et al., "M7.1 Report on the CD34 Cluster Workshop," ed. Knapp, et al., at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 818.
Lansdorp et al., "M7.2 CD34 Epitopes," ed. Knapp, et al., at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 826.
Molgaard et al., "M7.3 Molecular Characterization of Human and Murine CD34," ed. Knapp, et al. at the Fourth International Workshop and Conference on Human Leucocyte (1989), Oxford Univ. Press, p. 827.
Civin, C. I., "Antigenic Analysis of Hematopoieses III. a Hematopoietic Progenitor Cell Surface Antigen Defined by a Monoclonal Antibody Raised Against KG-Ia Cells" (1984), J. Immunology 133:157-165.
Civin Strauss et al., (1982) Blood 60(5):95a (abstract).
Civin, Vaughan et al., "Cell Surface Antigens of Human Myeloid Cells", (1982) Exp. Hematol. 10:129 (abstract).
Civin, Brovall et al. (1983) Hybridoma 2:125a, presented Feb. 8, 1983, abstracts available Feb. 6, 1983.
Brovall, Shaper, Civin et al. (1983) Exp. Hematol. II (Supp.):199, presented Jul. 14, 1983, abstract available Jul. 10, 1983.
Civin, Vaughan, et al. (1983) Exp. Hematol. II (Supp.):84, presented Jul. 12, 1983, abstract available Jul. 10, 1983.
Strauss and Civin (1983) Exp. Hematol. II:205, presented Jul. 14, 1983, abstracts available Jul. 10, 1983.
Strauss and LaRusa and Civin (1984) I.S.E.H. Abstract.
Leary, Ogawa, Civin et al. (1984) I.S.E.H. Abstract.
Bodger, et al., "Surface Antigenic Determinants on Human Pluripotent and Unipotent Hematopoietic Progenitor Cells", Blood, vol. 61, pp. 1006-1010 (1983).
Bodger et al., "A Monoclonal Antibody Specific for Immature Hematopoietic Cells and T. Lineage CElls", J. Immunology, pp. 2269-2274 (1981).
Nadler et al. (1981) Prog. Hematol. 12:187-225.
Reinherz et al. (1980) N. Engl. J.Med. 303:370.
Ritz et al. (1980) Nature 283:583.
Stashenko et al. (1980) J. Immunol. 125:1678.
Winchester et al. (1977) Proc. Nat'l. Acad. Sci U.S.A., 74:4012.

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