Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Hemic or immune system
Patent
1991-03-22
1992-07-14
Doll, John
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Hemic or immune system
4352402, A61K 3528, C12N 508
Patent
active
051301440
ABSTRACT:
Monoclonal antibodies that recognize a stage-specifc antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marror transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as theraputic methods employing the cell suspensions.
REFERENCES:
patent: 4364932 (1982-12-01), Kung et al.
patent: 4364937 (1982-12-01), Kung et al.
patent: 4381292 (1983-04-01), Bieber et al.
patent: 4381295 (1983-04-01), Kung et al.
patent: 4443427 (1984-04-01), Reinherz et al.
patent: 4582797 (1986-04-01), Trowbridge et al.
patent: 4624925 (1986-11-01), Kung et al.
patent: 4710457 (1987-12-01), Dupont et al.
Preschel et al., "M7 Cluster Rept: CD34", ed. Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 817.
Civin et al., "M7.1 Rept on the CD34 Cluster Workshop", ed. Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 818.
Lansdrop et al., "M7.2 CD34 Epitopes", ed. Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 826.
Molgaard et al., "M7.3 Molecular Characterization of Human and Murine CD34", ed, Knapp, at the Fourth Int'l Workshop and Conference on Human Leucocyte (1989), p. 827.
Civin et al., "Antigenic Analysis of Hematopoiesis III. A Hematopoietic Progenitor Cell Surface Antigen Defined by a Monoclonal Antibody Raised Against KG-1a Cells", J. Immunology 133:157-165 (1984).
Civin et al., "Cell Surface Antigens of Human Myeloid Cells", (1982) Exp. Hematol. 10:129 (abstract).
Civin et al., "Characterization of Four Monoclonal Antibodies Reactive with Human Cell Subsets", Blood, 60(5):95a (abstract).
Civin et al., "Cell Surface Antigens by Four Monoclonal Antibodies Raised Against KG-1a Cells", Hybridoma, 2:125a (abstract).
Brovall et al., "Identification and Partially Characterization of Two Human Potential Hematopoietic Differentiation Antigens" Exp. Hematol. 11:(Supp.) 199 (abstract).
Civin et al., "Diagnostic and Prognostic Utility of Cell Surface Markers In Acute Non-Lymphocytic Leukemia" (ANLL), Exp. Hematol. 11:(Supp.)84.
Strauss et al., "MY-10, A Human Hematopoietic Progenitor Cell Surface Antigen Identified by a Monoclonal Antibody" Exp. Hematol. 11:205 (abstract).
Strauss, et al. "MY-10 Antigen is Lost at the CFU-E Stage During Erythroid Progenitor Cell Maturation", (1984) I.S.E.H. (Abstract).
Leary, et al., "Single Cell Origin of Human Multilineage Colonies", (1984) I.S.E.H. (Abstract).
Bodger, et al., "Surface Antigenic Determinants on Human Pluripotent and Unipotent Hematopoietic Progenitor Cells", (1983) Blood, 61:1006-1010.
Bodger, et al., "A Monoclonal Antibody Specific for Immature Human Hemopoietic Cells and T Lineage Cells", (1981) J. Immunology, 127:2269-2274.
Nadler et al., "Diagnosis and Treatment of Human Leukemias and Lymphomas Utilizing Monoclonal Antibodies" Prog. Hematol., 12:187-225.
Winchester, et al., "Expressin of Ia-like antigen molecules on human granulocytes during early phases of differentiation", Proc. Natl. Acad. Sci. USA 74:4012-4016 (1977).
Stashenko, et al., "Characterization of a Human B Lymphocyte-Specific Antigen" J. Immunology, 125:1678-1685 (1980).
Reinherz, et al., "Regulation of the Immune Response--Inducer and Suppresoor T-Lymphocyte Subsets in Human Beings" (1980) N. Engl. J. Med. 303:370.
Ritz, et al., "A Monoclonal Antibody to Human Acute Lymphoblastic Leukaemia Antigen" Nature 283:583-585.
Doll John
Elliott George C.
The Johns Hopkins University
LandOfFree
Human stem cells and monoclonal antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human stem cells and monoclonal antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human stem cells and monoclonal antibodies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-333595