Human stem cells

Details Human stem cells Human stem cells

1984-02-06

1987-12-22

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7, C12N 502, G01N 33577

Patent

active

047146800

ABSTRACT:
Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as theraputic methods employing the cell suspensions.

REFERENCES:
Strauss et al., `MY-10, A Human Hematopoietic Progenitor Cell Surface Antigen Identified by a Monoclonal Antibody`; Experimental Hematology (Lawrence), II (Suppl. 14); 1983, p. 205.
Bodger et al.; `Surface Antigenic Determinants on Human Pluripotent and Unipotent Hematopoietic Progenitor Cells`; Blood, vol. 61, No. 5; May, 1983, pp. 1006-1010.
Bodger et al., `A Monoclonal Antibody Specific for Immature Human Hematopoietic Cells and T Lineage Cells`; J. Immunology, vol. 127, No. 6, Dec. 1981; pp. 2269-2274.
Civin, Strauss et al., Blood 60(5):95a (Abstract) (1982).
Civin, Vaughan et al., "Cell Surface Antigens of Human Myeloid Cells," (1982) Exp. Hematol. 10:129 (Abstract).
Civin, Brovall et al., Hybridoma 1:125a, (1983), presented Feb. 8, 1983, abstracts available Feb. 6, 1983.
Brovall, Shaper, Civin et al., Exp. Hematol. II (Supp.):199 (1983), presented Jul. 14, 1983, abstract available Jul. 10, 1983.
Civin, Vaughan et al., Exp. Hematol. II (Supp.):84, (1983), presented Jul. 12, 1983, abstract available Jul. 10, 1983.
Strauss & Civin, Exp. Hematol, II:205 (1983), presented Jul. 14, 1983, abstracts available Jul. 10, 1983.
Strauss & LaRusa and Civin, I.S.E.H. Abstract (1984).
Leary, Ogawa, Civin et al., I.S.E.H. Abstract (1984).
Civin et al., J. Immunology, (1984), vol. 13, 157-165.

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