Human splenin

Details Human splenin Human splenin

1987-05-22

1990-05-08

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530301, 530330, 514 12, 514 17, 514 21, 424 88, A61K 3702, C07C10352

Patent

active

049239643

ABSTRACT:
The present invention is directed to the protein human splenin (hsP), substantially free of material associated with the protein in its natural environment in the human spleen. In particular, the present invention relates to such isolated or synthesized human splenin having the amino acid residue sequence:
-GLY-LEU-PRO-LYS-GLU-VAL-PRO-ALA-VAL-LEU-THR-LYS-GLN-LYS -LEU-LYS-SER-GLU-LEU-VAL-ALA-ASN-ASN-VAL-THR-LEU-PRO-ALA -GLY-GLU-MET-ARG-LYS-ALA-VAL-TYR-VAL-GLU-LEU-TYR-LEU-GLY -SER-LEU-THR-ALA-GLU-HIS-.
Additionally, the present invention relates to a therapeutic composition of matter comprising a therapeutically effective amount of the hsP having the above sequence and a pharmaceutically acceptible carrier.

REFERENCES:
patent: 4190646 (1980-02-01), Goldstein et al.
Audhya et al., "Complete Amino Acid Sequences of Bovine Thymopoietins I, II, and III: Closely Homologous Polypeptides", Biochemistry, vol. 20, pp. 6195-6200, 1981.
Audhya et al., "Contrasting Biological Activities of Thymopoietin and Splenin, Two Closely Related Polypeptide Products of Thymus and Spleen", Proc. Natl. Acad. Sci. USA, vol. 81, pp. 2847-2849, 1984.

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