Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-05-20
2008-05-20
Robinson, Hope (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S006120, C435S069100, C435S007100, C800S008000, C530S350000, C514S002600, C514S012200
Reexamination Certificate
active
10467219
ABSTRACT:
The present invention provides polynucleotides and polypeptides of a human sphingosine-1-phosphate phosphatase, referred to herein as hSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the hSPP1 protein and polypeptides thereof, assays for the presence or expression of hSPP1 and assays for the identification of compounds that interact with hSPP1.
REFERENCES:
patent: 6667163 (2003-12-01), Mandala et al.
Van Veldhoven, Direct Submission, Accession No. HSA293294, Sep. 7, 2000.
Goetzl and An, “Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate”, FASEB J., vol. 12, pp. 1589-1598 (1998).
Spiegel, “Sphingosine 1-phosphate: a prototype of a new class of second messengers”, Journal of Leukocyte Biology, vol. 65, pp. 341-344 (Mar. 1999).
Hisano et al., “Induction and Suppression of Endothelial Cell Apoptosis by Sphingolipids: A Possible in Vitro Model for Cell-Cell Interactions Between Platelets and Endothelial Cells”, Blood, vol. 93, No. 12, pp. 4293-4299 (Jun. 15, 1999).
Wang, et al., “Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor”, The Journal of Biological Chemistry, vol. 274, No. 50, pp. 35343-35350 (Dec. 10, 1999).
Lee et al., “Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate”, Cell, vol. 99, pp. 301-312 (Oct. 29, 1999).
Postma et al., “Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor”, The EMBO Journal, vol. 15, No. 10, pp. 2388-2392 (1996).
Van Brocklyn et al., “Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218”, The Journal of Biological Chemistry, vol. 274, No. 8, pp. 4626-4632 (Feb. 19, 1999).
van Koppen et al., “Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate”, The Journal of Biological Chemistry, vol. 271, No. 4, pp. 2082-2087 (Jan. 26, 1996).
Yamamura et al., “Sphingosine 1-Phosphate Regulates Melanoma Cell Motility through a Receptor-Coupled Extracellular Action and in a Pertussis Toxin-Insensitive Manner”, Biochemistry, vol. 36, pp. 10751-10759 (1997).
Olivera et al., “Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens”, Nature, vol. 365, pp. 557-560 (Oct. 1993).
Choi, et al., “Calcium mobilization via sphingosine kinase in signalling by the FeεRI antigen receptor”, Nature, vol. 380, pp. 634-636 (Apr. 1996).
Melendez et al., “FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking”, The Journal of Biological Chemistry, vol. 273, No. 16, pp. 9393-9402 (Apr. 17, 1998.
Xia et al., “Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 14196-14201 (Nov. 1998).
Kleuser et al., “1α,25-Dihydroxyvitamin D3 Inhibits Programmed Cell Death in HL-60 Cells by Activation of Sphingosine Kinase”, Cancer Research, vol. 58, pp. 1817-1824 (May 1, 1998).
Meyer zu Heringdorf et al., “Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors”, The EMBO Journal, vol. 17, No. 10, pp. 2830-2837 (1998).
Mattie et al., “Sphingosine-1-phosphate, a Putative Second Messenger, Mobilizes Calcium from Internal Stores via an Inositol Trisphosphate-independent Pathway”, The Journal of Biological Chemistry, vol. 269, No. 5, pp. 3181-3188 (1994).
Rani et al., “Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors”, The Journal of Biological Chemistry, vol. 272, No. 16, pp. 10777-10783 (Apr. 18, 1997).
Van Brocklyn et al., “Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival”, The Journal of Cell Biology, vol. 142, No. 1, pp. 229-240 (Jul. 13, 1998).
Cuvillier et al., “Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate”, Nature, vol. 381, pp. 800-803 (Jun. 1996).
Perez et al., “Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction”, Nature Medicine, vol. 3, No. 11, pp. 1228-1232 (Nov. 1997).
Edsall et al., “Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation”, The Journal of Neuroscience, vol. 17, No. 18, pp. 6952-6960 (Sep. 15, 1997).
Cuvillier et al., “Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly (ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes”, The Journal of Biological Chemistry, vol. 273, No. 5, pp. 2910-2916 (Jan. 30, 1998).
Olivera et al., “Purification and Characterization of Rat Kidney Sphingosine Kinase”, The Journal of Biological Chemistry, vol. 273, No. 20, pp. 12576-12583 (May 15, 1998).
Kohama et al., “Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase”, The Journal of Biological Chemistry, vol. 273, No. 37, pp. 23722-23728 (Sep. 11, 1998).
Nagiec et al., “The LCB4 (YOR171c) and LCB5 (YLR260w) Genes ofSaccharomycesEncode Sphingoid Long Chain Base Kinases”, The Journal of Biological Chemistry, vol. 273, No. 31, pp. 19437-19442 (Jul. 31, 1998).
Olivera et al., “Sphingosine Kinase Expression Increases Intracellular Sphingosine-1 phosphate and Promotes Cell Growth and Survival”, The Journal of Cell Biology, vol. 147, No. 3, pp. 545-557 (Nov. 1, 1999).
Spiegel et al., “Sphingolipid metabolism and cell growth regulation”, The FASEB Journal, vol. 10, pp. 1388-1397 (Oct. 1996).
Mandala et al., “Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 150-155 (Jan. 1998).
Gottlieb et al., “The DPL1 Gene Is Involved in Mediating the Response to Nutrient Deprivation inSaccharomyces cerevisiae”, Molecular Cell Biology Research Communications, vol. 1, pp. 66-71 (1999).
Mao et al., “The dihydrosphingosine-1-phosphate phosphatases ofSaccharomyces cerevisiaeare important regulators of cell proliferation and heat stress responses”, Biochem. J., vol. 342, pp. 667-675 (1999).
Skrzypek et al., “Analysis of Phosphorylated Sphingolipid Long-Chain Bases Reveals Potential Roles in Heat Stress and Growth Control inSaccharomyces”, Journal of Bacteriology, vol. 181, No. 4, pp. 1134-1140 (1999).
Saba et al., “The BST1 Gene ofSaccharomyces cerevisiaeIs the Sphingosine-1-phosphate Lyase”, The Journal of Biological Chemistry, vol. 272, No. 42, pp. 26087-26090 (1997).
Mandala et al., “Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response”, Proc. Natl. Acad. Sci. USA, vol. 95, pp. 150-155 (Jan. 1998).
Mao et al., “Identification and Characterization ofSaccharomyces cerevisiaeDihydrosphingosine-1-phosphate Phosphatase”, The Journal of Biological Chemistry, vol. 272, No. 45, pp. 286090-28694 (Nov. 7, 1997).
Stukey et al., “Identification of a novel phosphatase sequence motif”, Protein Science, vol. 6, pp. 469-472 (1997).
Toke et al., “Isolation and Characterization of theSaccharomyces cerevisiaeLPP1 Gene Encoding a Mg2+independent Phosphatidate Phosphatase”, The Journal of Biological Chemistry, vol. 273, No. 23, pp. 14331-14338 (Jun. 5, 1998).
Toke et al
Mandala Suzanne M.
Thornton Rosemary A.
Heber Sheldon O.
Merck & Co. , Inc.
Robinson Hope
Yablonsky Michael D.
LandOfFree
Human sphingosine-1-phosphate phosphatase and inhibition... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human sphingosine-1-phosphate phosphatase and inhibition..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human sphingosine-1-phosphate phosphatase and inhibition... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3914584