Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1998-10-13
2000-01-25
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
435193, A61K 3851, C12N 910
Patent
active
06017529&
ABSTRACT:
The present invention provides a human spermidine/spermine N1-acetyltransferase (S-ACTR) and polynucleotides which identify and encode S-ACTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding S-ACTR and a method for producing S-ACTR. The invention also provides for use of S-ACTR and agonists, antibodies, or antagonists specifically binding S-ACTR, in the prevention and treatment of cancers. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding S-ACTR for the treatment of diseases associated with the expression of S-ACTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, or antibodies specifically binding S-ACTR.
Achutamurthy Ponnathapura
Incyte Pharmaceuticals Inc.
Slobodyansky Elizabeth
LandOfFree
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