Human source leading sequence, gene vector and gene...

Details Human source leading sequence, gene vector and gene... Human source leading sequence, gene vector and gene...

2007-07-24

2007-07-24

Strzelecka, Teresa E. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200

Reexamination Certificate

active

10333069

ABSTRACT:
The present invention provides a human source gene targeting sequence a gene vector and gene expression strategies. The invention includes the following: (1) Using a DNA sequence without important physiological function-related genes in the short arms of human group D, G chromosomes, or a DNA sequence sharing 50% or over 50% identity to the sequence selected from human D, G group chromosomes, as a targeting sequence for gene targeting and (2) Construction of a gene vector containing the targeting sequence. the nucleolus organizing region in D, G group chromosomes that is described above is used as the target site, the gene of interest is integrated into the short arms where the gene expresses actively in D,G group chromosomes of human cells. The present invention provides a novel gene targeting sequence by which the gene vector construction and gene expression strategies are realized. The gene expression strategies can be used for human gene therapy and for manufacturing protein.

REFERENCES:
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patent: 5843757 (1998-12-01), Vogelstein et al.
The Sanger Centre et al. Toward a complete human genome sequence. 1998. Genome Research. 8:1097-1108.
NCBI genebank accession data, Mar. 5, 1999.
Frengen et al. Abstract DOE Human Genome Program Contractor-Grantee Workshop IV. Nov. 1994.
Rodrguez et al. J. Virology vol. 63:997-1001. 1989.

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