Human skeletal muscle-specific ubiquitin-conjugating enzyme

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387100, C530S388100, C530S389100

Reexamination Certificate

active

08048995

ABSTRACT:
The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

REFERENCES:
patent: 5863779 (1999-01-01), Lal
patent: 5952181 (1999-09-01), Lal
patent: 96/36709 (1996-11-01), None
patent: 2004072100 (2004-08-01), None
Database EMBL (Online), 1996, Database Accession No. U4824.
Watanabe T K, et al, “Cloning and Characterization of Two Novel Human cDNAS (NELL1 and NELL2) Encoding Proteins with Six EGF-Like Repeats,” Genomics, 1996, 38(3): 273-276.
Kuroda S, et al, “Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins Nell1 and Nell2,” Biochemical and Biophysical Research Communications, vol. 265, No. 1, 1999, pp. 79-86, Academic Press Inc., Orlando, FL.
Kuroda S, et al, “Involvement of Epidermal Growth Factor-Like Domain of Nell Proteins in the Novel Protein Interaction with Protein Kinase C,” Biochemical and Biophysical Research Communications, vol. 265, No. 3, 1999, pp. 752-757, Academic Press Inc., Orlando, FL.
Okamoto K, et al, “Identification of NAD+-Dependent Isocitrate Dehyrdogenase 3 γ-Like (IDH3GL) Gene and Its Genetic Polymorphisms,” Gene, 2003, 323: 141-148.
Zhang X, et al, “Craniosynostosis in Transgenic Mice OverexpressingNell-1,” Journal of Clinical Investigation, 2002, 110(6): 861-870.
Zhang X, et al, “Overexpression ofNELL-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development,” Journal of Bone and Mineral Research, 2003, 18(12): 2126-2134.
Luce M J, et al, “The Neuronal EGF-Related GenesNELL1andNELL2are Expressed in Hemapoietic Cells and Developmentally Regulated in the B Lineage,” Gene, 1999, 231: 121-126.
Ting K, et al, “HumanNELL-1Expressed in Unilateral Coronal Synostosis,” Journal of Bone and Mineral Research, 1999, 14(1): 80-89.
Clone GEN-501D08, Moffett et al,EMBO J., 12:339-347 (1993).
Clone Gene-080G1, Genbank Database Accession No. D49738 (1997).
Clone GEN-025F07, Genbank Database Accession Nos. Z4991, L34070, U19530 and X59720 (1994).
Clone GEN-076C09, Franzé et al,Genomics, 9(4):728-736 (1991), Abstract.
Clone GEN-331G07, Shibuya et al,Nature, 357(6380):700-702 (1992), Abstract.
Clone GEN-163D09, Genbank Database Accession No. Z49154 (1999).
Clone GEN-078D05, Simon et al,Biochem. J., 297(Pt2):389-397 (1994), Abstract.
Clone GEN-432A12, Genschik et al,Mol. Gen. Genet., 244(5):548-556 (1994), Abstract.
Clone GEN-092E10, Genbank Database Accession No. U19878 (1995).
Clone GEN-428B12, Sun et al,Mol. Cell Biol., 15(1):564-565 (1995), Abstract.
Clone GEN-073E05, Spritz et al,Genomics, 22(2):425-430 (1994), Abstract.
Clone GEN-093E05, Matshuhashi et al,Dev. Dyn., 203(2):212-222 (1995), Abstract.
Clone GEN-077A09, Hoshino et al,EMBO J., 8(12):3807-3814 (1989), Abstract.
Takahashi et al,Hum. Genet., 86:14-16 (1990).
Cherif et al,Proc. Natl. Sci, USA, 87:6634-6638 (1990).
Fujiwara et al,DNA Research, 2:107-111 (1995).
Takashi et al,Human Genet., 88:119-121 (1991).
Peterson et al,J. Biol. Chem., 271(47):29903-29908 (1996).
Eib et al, “A novel Transmembrane Protein Containing Two Follistatin Modules and an EGF Domain”, Database Accession No. U19878.1, Abstract XP002289426 (Apr. 2, 1995).
Rupp et al, “Structure and Chromosomal Localization of the Mammalian Agrin Gene”, J. of Neuroscience, 1992, 12(9):3535-3544.
Uchida et al, “A Novel Epidermal Growth Factor-like Molecule Containing Two Follistatin Modules Stimulates Tyrosine Phosphorylation of erbB-4 in MKN28 Gastric Cancer Cells”, Biochemical and Biophysical Res. Comm., 1999, 266: 593-602.
Glynne-Jones et al, “TENB2, A Proteoglycan Identified in Prostate Cancer that is Associated with Disease Progression and Androgen Independence”, Int'l. J. of Cancer, 2001, 94(2): 178-184.
Liang et al, “The Gene for a Novel Transmembrane Protein Containing Epidermal Growth Factor and Follistain Domains Is Frequently Hypermethylated in Human Tumor Cells”,Cancer Res., 2000, 60(17): 4907-4912.
Attwood, T, Science, “The Babel of Bioinformatics”, 2000, 290(5491): 471-473.
Gerhold et al, “It's the genes! EST access to human genome content”, BioEssays, 1996, 18(12): 973-981.
Russell et al, “Structural Features can be Unconserved in Proteins with Similar Folds”, Journal of Molecular Biology, 1994, 244: 332-350.
Wells et al, “The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and Expressed Sequence Tag Databases”, Journal of Leukocyte Biology, 1997, 61(5): 545-550.
Guo et al, “Protein tolerance to random amino acid change”, PNAS, USA, 2004, 101(25): 9205-9210.
Aihara Koutoku et al: “A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases.”Brain Research Molecular Brain Research Aug. 19, 2003 LNKD-PUBMED:12941464, vol. 116, No. 1-2, (Aug. 19, 2003), pp. 86-93, ISSN: 0169-328X, Abstract.
Maeda K et al: “Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors.”Neurologia Medico-Chirurgica Dec. 2001 LNKD-PUBMED:11803583, vol. 41, No. 12, Dec. 2001, pp. 582-588: DIS, ISSN: 0470-8105, Abstract.
Matsuhashi S.; et al, 1995, “New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos. ”, Developmental dynamics, Jun. 1995, vol. 203, NR-2, PG-212-222, XP0009057037.
Office Action dated Feb. 16, 2011 issued in corresponding European Patent Application No. 07014998.4.
European Search Report issued in application No. 10182760.8-1212 dated Dec. 8, 2010.
Database EMBL,“Rattus norbegicus protein kinase C-binding protein NELL1 mRNA, complete cds,” Feb. 23, 1996, Accession No. EMBL U48246.
Lichter et al. Proc. Natl. Acad. Sci., USA 87: 6634-6638 (1990).
Lucentini, The Scientist, 2004, 18:20.
Watanabe et al.: “Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans,” Cytogenet Cell Genet 1996;74:146-148.
Japanese Office Action issued in JP 2004-041767 issued May 16, 2007.
Wilson R. et al.: “2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans”, Nature 368 (6466), 32-38 (1994).
Wilson R. et al., “Probable Ubiquitin-Conjugating Enzyme E2-19 KD (Ubiquitin-Protein Ligase) (Ubiquitin Carrier Protein)” DATABASE GenBank accession No. P34477, Jun. 1994.
Comparison showing the revision history of Genbank accession No. P34477: the top row is the present information of the “LIVE” P34477 dated Mar. 8, 2011 and the bottom row is the information of P34477 at the point of Mar. 25, 1994.
Comparison showing changes made to the Genbank accession No. P34477 record from the present information with respect to the information at the point of Jun. 1, 1994 (marked in blue, updated on Mar. 25, 1994 10:46 PM) cited from the Database Genbank accession No. P34477.
Database accession No. AA113903, Nov. 30, 1996, EBI accession No. EM—EST:AA113903.
Database accession No. D78514, Dec. 21, 1996, EBI accession No. EM—HUM:D78514.
Database accession No. P34477, Feb. 1, 1994, EBI accession No. UNIPROT: P34477.
European Search Report dated Jun. 8, 2011, for European Patent Application No. 10185775.

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