Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-07
2000-11-14
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4242041, 4242051, 4242251, 4241891, 4352351, 4352361, 435237, 435320, A61K 3929, A61K 3912, C12N 700, C12N 704
Patent
active
061466433
ABSTRACT:
The present invention relates, in general, to a substantially pure preparation of the simian hepatitis A viral isolate AGM-27; a substantially pure preparation of the genomic DNA of simian hepatitis A viral isolate AGM-27; a pharmaceutical composition comprising the simian hepatitis A viral isolate AGM-27; a method of preventing hepatitis A in an animal; and a vaccine comprising the simian hepatitis A viral isolate AGM-27.
REFERENCES:
patent: 4894228 (1990-01-01), Purcell et al.
Khanna et al.; Characterization of a Genetic Variant of Human Hepatitis A Virus, J. Med. Virol., 36:118-124(1992).
Andzhaparidze et al., Spontaneous Hepatitis, Similar to Hepatitis A in African Green Monkeys, Voprosy Virusologii, 6:681-686 (1987).
Cohen et al., Complete Nucleotide Sequence of Wild-Type Hepatitis A Virus: Comparison with Different Strains of Hepatitis A Virus and Other Picornaviruses, J. Virol., 61:50-59 (1987).
Cohen et al., Attenuation and Cell Adaptation of Hepatitis A Virus (HAV): A Genetic Analysis with HAV cDNA, J. Virol., 63:5364-5370 (1989).
Cohen et al., Hepatitis A Virus cDNA and Its RNA Transcripts Are Infectious in Cell Culture, J. Virol., 61:3035-3039 (1987).
Brown et al., Characterization of a Simian Hepatitis A Virus (HAV) Antigenic and Genetic Comparision with Human HAV, J. Virol., 63:4932-4937 (1989).
Balayan et al., Variations in Genome Fragments Coding for RNA Polymerase in Human and Simian Hepatitis A Viruses, Febs Lett., 247:425-428 (1989).
Cohen et al., Complete Nucleotide Sequence of an Attenuated Hepatitis A Virus: Comparison with Wild-Type Virus, Proc. Natl. Acad. Sci., 84:2497-2501 (1987).
Tsarev et al., Simian Hepatitis A Virus (HAV) Strain AGM-27:Comparison of Genome Structure and Growth in Cell Culture with Other Have Strains, J. Gen. Virol., 72:1677-1683 (1991).
Lemon et al., Genomic Heterogeneity Among Human and Non-Human Strains of Hepatitis A Virus, J. Virol., 61:735-742 (1987).
Cohen et al., J. Virol., 63:5364-5370, 1989.
Emerson Suzanne U.
Purcell Robert H.
Tsarev Sergei A.
The United States of America as represented by the Secretary of
Williams Jay
Woodward Michael P.
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