Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-12-15
1999-10-05
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435375, 435325, 435 701, 536 231, 536 243, 536 245, 514 44, C12N 1500, C12N 1563, C07H 2104, A61K 4800
Patent
active
059622652
ABSTRACT:
A novel human signal-transduction kinase polypeptide is described which is expressed at a particularly high level in tissues of the human immune system. A full length cDNA which encodes the novel signal transduction serine/threonine kinase polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the native biological molecule. Methods are provided to identify compounds that modulate the biological activity of the human Ste20-like serine/threonine signal transduction kinase.
REFERENCES:
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Friedemann Kiefer .sup.1.2 , et al., HPK1, A Hematopoietic Protein Kinase Activating the SAPK/JNK Pathway, The Embo Journal, 15/24:7013 (1996).
Creasy, Caretha L., et al., Cloning and Characterization of a Member of the MST Subfamily of Ste20Like Kinases, Gene, 167:303 (1995).
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Creasy, Caretha L., et al., Cloning and Characterization of a Human Protein Kinase with Homology to Ste-20, The Journal of Biological Chemistry, 270:21695 (1995).
Pombo, Cella M. et al., Activation of the SAPK Pathway by the Human STE20 Homologue Germinal Centre Kinase, Nature, 377:750 (1995).
Creasy, Caretha L., et al., The Ste20-like Protein Kinase, Mst1, Dimerizes and Contains and Inhibitory Domain, The Journal of Biological Chemistry, 271:21049 (1996).
Hanks, Steven K., et al., Protein Kinases 6--The Eukaryotic Protein Kinase Superfamily: Kinase (Catalytic) Domain Structure and Classification.sup.1 , The FASEB Journal, 9:578 (1995).
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Moore William Craig
Norris Tyrrell Errick
Silberstein David Shay
Degen Nancy
Epps Janet
Higgins Patrick H.
Zeneca Limited
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