Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-06-25
2000-03-07
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, 536 2431, 536 2433, 435 911, 4352523, 4352542, 4353201, 435325, C07H 2104, C12N 1563, C12N 1585, C12N 1586, C12N 121
Patent
active
060342285
ABSTRACT:
An isolated and purified human Ste20-like serine/threonine signal transduction kinase is described. A cDNA sequence which encodes the native signal transduction molecule is disclosed as well as the structural coding region and the amino acid residue sequence. Methods are provided which employ the sequences to identify compounds that modulate the biological and/or pharmacological activity of the transduction molecule and hence regulate cell physiology. Biologically-effective antisense molecules, as well as dominant negative mutant versions of the biomolecule are described which are suitable for therapeutic use. The invention is also drawn toward the diagnosis, prevention, and treatment of pathophysiological disorders mediated by the signal transduction molecule.
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Moore William Craig
Norris Tyrrell Errick
Silberstein David Shay
Elliott George C.
Epps Janet
Higgins, Esq. Patrick H.
Zeneca Limited
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